Hemophilia?

Question

I know that hemophilia is a genetic disorder where in the clotting is disrupted. but what essential aspect of the clotting process is effected??? can anyone help?

Answer 1

Hemophilia is a hereditary bleeding disorder of specific blood clotting factors. There are several types of hemophilia, including hemophilia A and B.
Hemophilia A results from a deficiency (lack) of clotting factor VIII.
The disorder is caused by an inherited X-linked recessive trait, with the defective gene located on the X chromosome. That means the disorder occurs primarily in males. Females carry two copies of the X chromosome, so if the factor VIII gene on one chromosome doesn't work, the gene on the other chromosome can do the job. Males, however, carry only one X chromosome, so if the factor VIII gene on that chromosome is broken, they will have hemophilia A.
Hemophilia A is 7 times more common than hemophilia B. Hemophilia B is the result of a deficiency of clotting factor IX.
The disorder is caused by an inherited X-linked recessive trait, with the defective gene located on the X chromosome. Thus, the disorder occurs primarily in males. Females carry two copies of the X chromosome, so if the factor IX gene on one chromosome is defective, the other can compensate. Males, however, carry only one X chromosome, so if the factor IX gene on that chromosome is defective, they have the disease.
Von Willebrand disease is the most common hereditary bleeding disorder which affects both men and women.
Please see the web pages for more details on Hemophilia, Hemophilia A, Hemophilia B and Von Willebrand disease.

Answer 2

Hemophilia (or haemophilia - that's how I normally spell it) is caused by a deficiency of a clotting factor in the coagulation cascade (intrinsic part). Usually deficiency of clotting factor VIII (Haemophilia A)

Haemophilia B is the lack of factor IX

Haemophilia C is the lack of factor XI

Haemophilia A is most common.

Have a look at the wiki page and the diagram of the coagulation cascade (below).