Can anyone help me out, what is the pathophysiology for systemic lupus erythematosus?

Answer 1

Systemic lupus erythematosus (SLE or lupus) is a chronic autoimmune disease that is potentially debilitating and sometimes fatal as the immune system attacks the body’s cells and tissue, resulting in inflammation and tissue damage. SLE can affect any part of the body, but most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys and nervous system. The course of the disease is unpredictable, with periods of illness (called flares) alternating with remission. Lupus can occur at any age, but is most common in women, particularly of non-Caucasian descent.[1] Lupus is treatable symptomatically, mainly with corticosteroids and immunosuppressants, though there is currently no cure.


Pathophysiology: Autoantibodies, circulating immune complexes, and T lymphocytes all contribute to the expression of disease. Organ systems affected include dermatologic, renal, central nervous system (CNS), hematologic, musculoskeletal, cardiovascular, pulmonary, the vascular endothelium, and gastrointestinal. The revised criteria for SLE must include 4 of the following at any time during a patient's history (specificity 95% and sensitivity 75%):

Answer 2

Dopamine receptors in the brain rapidly lose their ability to function. That translates into a rapid decline of all muscular control. Ultimately the victim suffers a heart attack. It takes about 5 years on average to kill a person. It's believed that the effect on the receptors is secondary to the pathogen's infection of spinal fluid.

Answer 3

call your doc he or she will help you