What is Lymphoid Hyperplasia?

Question

I have a lot of stomach problems. I recently got an upper GI and small bowel series. I definately have IBS. Now the gastorenterologist saw something in the x-ray that he called lymphoid hyperplasia. I am not sure what it means and he also said the term is rare. He said that this was found in the distal illeum. I got a colonoscopy which was normal. He asked for me to get a capsule endoscopy because you can only view the small bowel closely this way. I havent found a doctor to give me that test. Should I be worried, and what is it?

Answer 1

Here this might help you out:
Lymphoid hyperplasia of the intestines is a benign reactive process also known as pseudolymphoma, lymphonodular hyperplasia, or terminal lymphoid ileitis.1 It occurs in all age groups, but is best described in children.1,2 There are no definitions or valid criteria for when normal lymphoid tissue becomes hyperplastic, or for when hyperplasia becomes pathologic.3 The dividing line between physiologic nodules and hyperplasia is thus ill-defined. Lymphoid hyperplasia may be discovered incidentally, at colonoscopy, or in patients undergoing colectomy, especially in the last few centimeters of the terminal ileum. However, cases that are symptomatic due to intussusception or prolapse are well documented.12 Lymphoid hyperplasia occurs mainly in the rectum and in the ileocecal region.1 Eighty percent of lymphoid polyps are sessile and solitary; the remainder are pedunculated and/or multiple (numbering 2 to 6).

Several causes of lymphoid hyperplasia have been postulated. Giardin lamblia is often present. In a small minority, immunodeficiencies underlie the hyperplastic state.2 Some patients have low or absent IgA and IgM levels, decreased IgG levels, susceptibility to infection, and diarrhea with or without steatorrhea. There is also an association with familial adenomatous polyposis and Gardner syndrome. In children, lymphoid hyperplasia is often associated with viral infection.

The pathology of lymphoid hyperplasia is quite characteristic, consisting of prominent lymphoid follicles with active germinal centers located in the mucosa and submucosa. The most important differential diagnosis is with lymphomatous polyposis. The presence of highly reactive germinal centers, numerous cell types, prominent vascularity, and polyclonality as determined immunohistochemically are the most important features in the differential diagnosis with lymphoma. Lymphoid hyperplasia may be differentiated from follicular lymphoma presenting as lymphomatous polyposis by Bcl-2 immunostaining of follicular germinal centers.

The clinical significance of lymphoid hyperplasia lies in the possibility of these nodules serving as a nidus for prolapse and intussusception and in the association with immunosuppressive states. Local excision is curative; occasionally, spontaneous remission has been noted.

Answer 2

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What is Lymphoid Hyperplasia?
I have a lot of stomach problems. I recently got an upper GI and small bowel series. I definately have IBS. Now the gastorenterologist saw something in the x-ray that he called lymphoid hyperplasia. I am not sure what it means and he also said the term is rare. He said that this was found in the...

Answer 3

Lymphoid hyperplasia is the rapid growth (proliferation) of normal cells that resemble lymph tissue.
Please see Google search for more details on Lymphoid hyperplasia and Capsule endoscopy.

Answer 4

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