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NHLBI: What Is Coronary Artery Disease?
Discusses coronary artery disease and its other names, causes, risks, symptoms, diagnosis, prevention, and treatments.www.nhlbi.nih.gov/health/dci/Diseases/Cad/CAD_WhatIs.html - 14k - Cached - More from this site -
Coronary Artery Disease
Coronary artery disease - Cleveland Clinic Heart & Vascular Institute, leader in ... (CTA), may change the way coronary artery disease is diagnosed in the future. ...clevelandclinic.org/heartcenter/pub/guide/.../cad/understandingcad.htm - 38k - Cached - More from this site -
MedlinePlus: Coronary Artery Disease
Coronary Artery Bypass Surgery. Heart Attack. Heart Diseases. Blood, Heart and Circulation ... Article: Premature coronary artery disease in Indians and ...www.nlm.nih.gov/medlineplus/coronaryarterydisease.html - 71k - Cached - More from this site - Save
This story appears in the December 1, 2003 print edition of U.S. News & World Report.
USNews.com: The heart, a special report
... an aged medical specialty, tracing its scientific origins back to 1628 and the ... Figuring out coronary artery disease, the biggest killer of men and women in ...www.usnews.com/usnews/health/articles/031201/1
Coronary artery disease - MayoClinic.com
Coronary artery disease — Comprehensive overview covers symptoms, treatment of this serious heart condition. ... Diseases & ConditionsDrugs & Supplements ...www.mayoclinic.com/health/coronary-artery-disease/DS00064 - 24k - Cached - More from this site -
Coronary Artery Disease
Features articles on coronary artery disease with a clinical emphasis. Includes observational studies, clinical trials, and advances in laboratory research.www.coronary-artery.com - More from this site - Save
Coronary Artery Disease - Texas Heart Institute Heart Information Center
Coronary Artery Disease (CAD) most often results from atherosclerosis which ... Diseases and Conditions > Heart Attack. Updated July 2006 ...texasheart.org/HIC/Topics/Cond/CoronaryArteryDisease.cfm - 40k - Cached - More from this site - Save
Coronary Artery Disease
Coronary artery disease - Cleveland Clinic Heart and Vascular Institute, leader ... With coronary artery disease, as you get older, the fat builds up, causing ...clevelandclinic.org/heartcenter/pub/guide/disease/cad/caddevelop.htm - 27k - Cached - More from this site -
coronary artery disease
treating coronary artery disease ... drugs, the progression of coronary artery disease can be completely arrested in many patients. ...heartdisease.about.com/library/ask/blaskdr005.htm - 25k - Cached - More from this site -
FDA Heart Health Online - Coronary Artery Disease
Heart Health Home > Conditions and Diseases > Coronary Artery Disease. Coronary Artery Disease ... and Blood Institute (NHLBI) Coronary Artery Disease ...www.fda.gov/hearthealth/conditions/coronaryarterydisease.html - 36k - Cached - More from this site -
Brief summary of coronary artery disease
Coronary Artery Disease - An OverviewHeart Attack : How exactly does it happen ? ... SyndromeTreatment options for coronary artery disease: An overv...heartdisease.about.com/cs/coronarydisease/a/CAD1.htm - 27k - Cached - More from this site - Save
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Answers 1 - 3 of 21 for Coronary Artery Disease
Coronary Artery Disease (CAD) found at initial stage.. can it be ...
... a coronary angiogram, a...in the arteries, and x-ray...extent of the disease, and if need...
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What is coronary artery disease?
Narrowing of these arteries, or they are plugged with placque.
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Lay dies of coronary artery disease?
While what you say is true, Lay had a LOT of stress in his life...like facing a potential lifetime jail...
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The heart and history: Prying open its secrets
No other bodily organ has inspired poets and philosophers over the centuries the way the human heart has
By Bernadine Healy, M.D.
Posted 11/23/03
The heart has a mind of its own. It is prone to flutter in response to a kiss, skip a few beats in the klieg lights, brace itself in the face of treachery, and slow during slumber--except, of course, during a nasty dream. This ever vigilant organ sustains all others by pumping up to 6 gallons of blood per minute and propelling it through some 60,000 miles of tributaries to bathe, nourish, and cleanse virtually every cell in the body. A beating heart is the joyous first sign of life, and it's the sad final thump that marks the moment of death. In today's secular times, the heart has lost much of its cachet as the mansion of the soul, but it has not lost its romantic and spiritual grip on us. We all still speak of happy hearts, good hearts, heavy hearts, and brave hearts. We have all felt heartache and have even been heartsick. We've suffered when our heart's desires were not fulfilled and been bewildered by those who are heartless. Our own hearts rally for the lionhearted and yearn with the Tin Man in his desperation for a heart. We see wellness in the heartland and know instinctively that home is where the heart is.
Romance aside, there is in reality no other organ that works so hard and faithfully yet is taken so for granted. But reality has a darker side as well. The sick heart can afflict the body with profound fatigue, crushing chest pain, dizzying rhythms, and frightening breathlessness. That is the heart that the cardiologist knows, and all too well.
Cardiology is an aged medical specialty, tracing its scientific origins back to 1628 and the epochal discoveries of the British physician William Harvey. This reputed father of cardiology is credited with bringing medicine from the Dark Ages into the light of science and inquiry. His major work, De Motu Cordis, arrived around the same time that Galileo was being persecuted for his heretical view that the Earth was not the center of the universe. Harvey faired better, since his radical thought--that the heart was the all-powerful center in a circular motion of blood--appealed to the clerics of the day.
It's fortunate he was "politically correct" because he was keenly accurate. He overturned the encrusted belief that blood originated in the liver, drew spirit from the heart, and merely sloshed to and fro in its vessels. Studying living animals and human corpses, he spoke the obvious: Arteries carried blood away from the heart, veins brought the blood back, under the command of the contracting heart, which orchestrated rhythm and powered a ceaseless, closed-loop circulation of blood. For Harvey the heart was a sovereign "internal creature" that nourished and preserved the body throughout life. What he didn't imagine was just how high maintenance this sovereign creature could be.
Curiosity and technology. The heart hid its tribulations well. It took a steady stream of technology to pry open its secrets in both sickness and health. For years physicians had been guided only by their bedside observations and an occasional epiphany from a stone-cold dissected heart. The stethoscope changed that, and that was sheer accident. In 1816, faced with the impropriety of listening to a young woman's chest by placing his ear on her bosom, French physician Rene Laennec devised a long thin tube to distance himself from the damsel. In the process he and others learned that this bit of manners actually amplified sound. Suddenly, doctors could listen to the rhythms of the heart and the opening and closing of heart valves. They could detect murmurs and hear crackles from the lungs that signaled early heart failure. By detecting valve disease, doctors came to understand its perilous relationship to cardiac enlargement and failure. Bigger biceps are strong, but bigger hearts are weak.
Valve problems became the face of 19th-century heart disease. Streptococcal infection was common and triggered rheumatic fever, which in turn caused grotesque valve malformations with thickening of the heart's walls and enlargement of its chambers. Cardiac syphilis caused huge calcified aortic aneurysms at the root of the heart and damaged the attached aortic valves. It was the stethoscope that picked up these previously unrecognized problems and set the stage for the focused pursuit of solutions. Indeed, penicillin in the next century would virtually wipe out both these diseases. In a recurrent cycle of seek and find, the stethoscope led to the external blood pressure cuff in 1905, which unveiled chronic hypertension, catalyzing a century of curative drug discovery.
Figuring out coronary artery disease, the biggest killer of men and women in modern times, has been slower going. In bygone years, chest pain was blamed on pneumonia or indigestion, and sudden death was an inexplicable, almost biblical event. One of the first hints that angina, sudden death, and coronary disease were linked came in 1793. John Hunter, a prominent surgeon troubled with bouts of chest pain, walked out of a hostile board meeting at St. George's Hospital, London, stifling his anger, and proceeded to groan and fall over dead in front of his colleagues (perhaps a prescient tale of a Type A personality). His renowned doctor, the discoverer of the pox vaccine, Edward Jenner, studied his autopsy, found "ossified" coronary arteries, and reasoned that they had caused the fatal weakness in his agitated heart.
To make sense of Hunter's storied demise, the Scottish anatomist Allan Burns designed a clever experiment, which he reported in 1809. It's still a neat trick for teaching medical students about alien concepts like "angina" and "ischemia." Recognizing that the heart was after all a muscle, he placed a tight tourniquet around the upper arm and then exercised the limb. In no time, profound fatigue and sickening pain set in and the arm falls immobile. Upon release of the tie, pain disappears and the muscle regains its life. Burns likened this to a stressed heart falling prey to narrowed arteries. Future generations of researchers confirmed his thinking, as did the 1903 Nobel Prize-winning discovery of the electrocardiogram by the Dutch scientist Willem Einthoven. With the EKG, doctors could detect ischemic heart muscle by changes in the electrical currents running through the injured part of the heart. EKGs also detected heart attacks, rhythm disorders, and the ventricular fibrillation of sudden cardiac death.
Another revolution was taking place about the same time in the autopsy room. Pathologists examining "ossified" coronary arteries found that they were actually plugged with fat-laden plaque. This suggested that these atheromas, as they were then called, came from cholesterol in the bloodstream or the diet. James Herrick of Rush University in Chicago discovered in 1912 that in heart attacks fresh blood clots had formed in arteries already narrowed by atheroma, pointing to the importance of the clotting system in this disease. The current "new" and popular culprit of coronary obstruction, inflammation, was actually suggested by these early pathologists. They observed that inflammatory cells were inveterate companions of the fatty plaques and seemed likely accomplices.
The one technology that most catapulted knowledge of the living heart was cardiac catheterization. The notion that one could touch the beating heart without peril was unthinkable in 1929. But Berlin's Werner Forssmann, fresh out of medical school, felt otherwise. When his professor dismissed his pipe dreams, Forssmann catheterized himself by threading a bladder catheter through an artery in his left arm into his heart. Catheter in place, he walked to radiology for a chest X-ray, the in-your-face proof that he had both succeeded and survived. His continued self-experimentation brought him more ridicule than recognition. Such boldness fared better in New York City, where 10 years later Andre Cournand and Dickinson Richards began catheterizing heart patients. This won all three physicians the Nobel Prize and, more important, changed cardiovascular medicine forever.
Catheterization became the looking glass and the portal for mending hearts. When in 1958 Mason Sones of the Cleveland Clinic discovered how to slip catheters directly into coronary arteries in motion and inject them with dye, the ability to detect coronary atheromas in living patients suddenly became reality. This opened the door for coronary artery bypass surgery and then, 20 years later, for coronary angioplasty, using catheters and stents instead of surgery to restore blood flow. Catheterization triggered other lifesavers. Intensive care units monitor sick patients with right-heart catheters. After transplant, the heart is biopsied through catheters to detect rejection. And electrical wires threaded into hearts enable permanently implanted pacemakers to sustain rhythm--or wait on standby to interrupt the drama of sudden death with a stored jolt of electricity.
Armed with knowledge of heart disease in its many forms, modern-day chemists and molecular biologists jumped in with their technologies. Bulging medicine cabinets, filled with ever more drugs to treat and prevent heart problems, are daily testimony to this, as are genetic, metabolic, and behavioral portraits that help people ward off their own heart risks. Now in our sights are therapies to reverse atherosclerosis with drugs and to restore vigor to damaged heart muscle with stem cells from marrow. Indeed, the boundless talent and technology that define cardiology have us on the very edge of declaring the death of today's scourge of coronary artery disease. It's not too early to wonder, What next?
This story appears in the December 1, 2003 print edition of U.S. News & World Report.
USNews.com: The heart, a special report
... an aged medical specialty, tracing its scientific origins back to 1628 and the ... Figuring out coronary artery disease, the biggest killer of men and women in ...www.usnews.com/usnews/healt... - 18k
I hope you'll find this article this quite helpful. It talks about its scientific origin in 1628 by william Harvey. In 1816 Rene Laennec for the discovery of the stethoscope. And the discovery of the EKG by a Dutch scientist, Willem Eithoven in 1903.
Good Luck!!!
2007-04-01 01:13:39
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answer #8
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answered by rosieC 7
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