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Fatty Acid Biosynthesis
• Synthesis takes place in the cytosol
• Intermediates covalently linked to acyl carrier protein
• Activation of each acetyl CoA.
• acetyl CoA + CO2 Malonyl CoA
• Four-step repeating cycle, extension by 2-carbons /
cycle
– Condensation
– Reduction
– Dehydration
– reduction
Fatty acid synthesis
• The enzymes of fatty acid synthesis are packaged together in
a complex called as fatty acid synthase (FAS).
• The product of FAS action is palmitic acid. (16:0).
• Modifications of this primary FA leads to other longer (and
shorter) FA and unsaturated FA.
• The fatty acid molecule is synthesized 2 carbons at a time
• FA synthesis begins from the methyl end and proceeds
toward the carboxylic acid end. Thus, C16 and C15 are
added first and C2 and C1 are added last.
• C15 and C16 are derived directly from acetylCoA. For
further step-wise 2-carbon extensions, acetylCoA is first
activated to malonyl CoA, a 3-carbon compound, by the
addition of a CO2.

2007-03-29 20:09:42 · answer #1 · answered by Ravinder C 2 · 0 0

Hi Magic. Synthesis is a more general term that can mean synthesis in the lab or in the body. Biosynthesis specifically means synthesis by the body (organism).

Best wishes.

2007-03-30 00:16:01 · answer #2 · answered by Doctor J 7 · 0 0

the 'bio' simply means the fatty acid synthesis takes place inside an organism...i think it is just not to be confused with fatty acids synthesized using chemicals in lab...

2007-03-30 00:16:03 · answer #3 · answered by Anonymous · 0 0

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