How do you know if a mouse has ALZHEIMER'S ??????

Answer 1

Post mortem inspection of the brain is still the best way to confirm it. How do the researchers get those kinds of mice? Easy, Alzheimer's is also a genetic disorder, so if you have two mice that have the disease, then you can breed them over and over to help get a good sample of mice that may have Alzheimer's. Then, once they have a good sample or mice that they "think" has Alzheimer's, then they can compare those mice results with a test group, which is called a control group.

Answer 2

There is a strain of mice that is bred with a mouse version of Alzheimers. The mouse is "normal" until it is fed a special food that causes the Alzheimers to become symptomatic. This is good because scientists can study the mouse's brain before and after the onset of the disease. After the onset of the disease a change can be seen in the mice. I work in a laboratory with mice and I can tell you that mice get used to having humans handle them. With time, most mice become less and less agitated and scared when their cage is opened. With Alzheimers mice however, they do not remember that they are handled on a daily basis, so every day working with them is like the first day they arrived at the lab. They are very scared, they run and hide, attempt to bite, the heart and respiration rates increase significantly, etc.... One of the most fascinating things that I see with them is that they forget where their water bottle is. In my facility the water bottles protrude from the top of the cage and normal mice gradually learn where their water source is. Alzheimers mice have to have a special jello-like water substance put on the floor of their cage so that they literally walk over it and find it. Otherwise these mice would not drink often and would become dehydrated. As the disease progresses to the end stage in the mice, they start to show late stage symptoms similar to humans like fatigue, paralysis, etc..

Answer 3

If you're talking about the testing of Alzheimer's drugs by using mice, they give them Alzheimers. They can test to see if they have the appropriate markers then they can tell if the new treatments make a difference.

Answer 4

By scanning the brain. Alzheimer's targets specific parts of the brain, memory first of all. By digitally scanning the brain, you can see the advancement of the disease. Plus, the scientist probably infected the DNA with the disease.

Answer 5

they breed the rats so theyre more likely to have amyloid plaques in their brain, which are a main cause of alzheimers. its easily detectable in an autopsy, but since they need them alive they probably run these high risk rats through mazes and tests like "I know nuttin" described to verify that the rat does have neurodegeneration

Answer 6

Alzhiemers creates very specific and measurable injury to the factors of the ideas that save reminiscence and character. This injury may be present in particularly much all mammals. This we could us be able to income the affliction in species different than people. because of the fact the mice that have been vaccinated in no way confirmed the effects of the affliction, it is theory that the vaccine is valuable.

Answer 7

surpisingly, my sister-in-law works in this area in barcelona. she works with rats. she cuts open a piece of their skull and gives messes with their brain then tries to fix it with meds or other treatments. anyways, the way you know a rat has alzheimers is by cutting open its skull and looking at it under a microscope. another surprising fact, did you know that the rat and human brains are 99% the same. crazy

Answer 8

If he's wearing a tin hat and ranting about the Vietnam War then he's gone barmy.

Answer 9

If it keeps going back to where the cheese used to be, but forgetting where the cheese is now.

Answer 10

Ask him his name. If he doesn't say anything and just looks at you funny, he's got it!