If used as an anesthetic gas, does Diethyl Ether get metabolized via biotransformation?

Question

Biotransformation typically results in intermediate metabolites that may be responsible for toxic after effects, such as inorganic fluoride and bromide ions.

Do only halogenated anesthetic gases (methoxyflurane, halothane, enflurane, desflurane, sevofulrane, isoflurane) undergo biotransformation and result in the production of inorganic fluoride and bromide ions?

Answer 1

Ether itself does not undergo biotransformation, but some of the other older anesthetics do (chloroform, trichloroethylene). Most of the newer halogenated gases (Iso, Des) don't get metabolized to an appreciable/dangerous extent but some of the older (Methoxyflurane) as well as newer (Sevo) halogenated gases do. Be careful grouping gases together as each one has a specific profile. Look them up in Miller's Anesthesia to find out about each one individually.