in nuclear transplantation?

Question

in nuclear transplantation, the nucleus of an adult somatic cell is transplanted to an egg which has had its original nucleus removed. the recipient cels then are diploid and can grow to become a healthy adult arganism. what can we conclude about the dna in the transplanted nucleus ? in what way if any has it changed while in the somatic cell

Answer 1

If the new cell begins to grow and differentiate, then we can conclude that (1) the DNA was intact, and (2) that the new cell is considered a zygote meaning undifferentiated. One major way that the DNA has changed from when it was in the somatic cell is that now many loci will be accessed for transcription and translation that would be ignored in a differentiated somatic cell.