Which can be heated more efficiently -- open-architectured or multi-room spaces?

Question

Assume everything else is equal -- btu's, humidification, appropriate placements of heating registers and vents, insulation, window/door placement,etc, which room would FEEL warmer or would there be no difference? Would one be more drafty than the other?

To clarify, this is to settle an argument over whether an open architected space is harder or easier of just the same to heat as a space of the same size which is divided into smaller rooms.

Answer 1

If both spaces have the same amount of cubic feet of air space and the heating units are identical and there is no restricted air flow in the multi-room space, there should be no difference. Especially if the air-exchange rate for the air-handling units are identical.

Answer 2

Multi roomed as one can have different temp levels based on comfort in each. Some cooler some warmer
Also, wanting one warmer, doesn't require all of them to be brought up to the same temp.