explain how hyrocortisone is an effect reduces cell damages and inflammation.?

Question

hydrocortisone is an anti-inflammatory drug that stabilizes lysosomal membranes.

Answer 1

Every cell in the body has glucocorticoid receptors. These receptors are located on the cell membrane as well as in the cytoplasm. When glucocorticoid steroids enter the cell cytoplasm by binding to the membrane receptor, binding to the carboxyl terminal of the receptor results in a conformational change. The DNA binding domain on the receptor become activated and the steroid-receptor complex attaches itself to the DNA after it travels to the nucleus. Such binding to DNA occur at specific nucleotide sequences, sites known as glucocorticoid responsive elements. These consensus sequences can be positive or negative depending on the ultimate effect on transcription at that promoter location. Accordingly, glucocorticoids can result in enhanced or repressed transcription of specific molecules. Glucocorticoids have a wide array of activity and affect virtually every cell in the immune system. In particular, the cells of the lymphoid origin are affected. It is indeed an old observation that lymphopenia occur during glucocorticoid excess. Function of T and B cells and macrophages are all affected, as also antigen presenting cells such as endothelial cells, microglia, and dendritic cells. Hydrocortisone like other glucocorticoids can augment transcription, resulting in enhanced production of one lymphokine, while causing repression and down-regulation of the production of another.
Lysosomal membranes are thus stabilised.

Answer 2

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