What is Nelson syndrome?

Answer 1

Nelson syndrome is an invasive and destructive ACTH-producing adenoma that occurs when there is adrenal removal directed at curing Cushing disease, thus removing cortisol production that would otherwise prevent further, excessive adenomatous growth.

Answer 2

This is a syndrome characterized by hyperpigmentation of the skin and enlargment of the sella turcica and caused by the development of a pituitary tumor following adrenalectomy for Cushing's syndrome. Also called postadrenalectomy syndrome.

Nelson's syndrome is the rapid enlargement of a pituitary adenoma that occurs after the removal of both adrenal glands.

Removal of both adrenal glands, or bilateral adrenalectomy, is an operation for Cushing's Disease. Removal of both adrenals eliminates production of cortisol, and the lack of cortisol's negative feedback can allow any preexisting pituitary adenoma to grow unchecked. Continued growth can cause mass effects due to physical compression of brain tissue, along with increased production of adrenocorticotrophic hormone (ACTH) and melanocyte stimulating hormone (MSH).

The common signs and symptoms include muscle weakness and skin hyperpigmentation due to excess MSH. Nelson's syndrome is rare because bilateral adrenalectomy is now only used in extreme circumstances.

Answer 3

"People who have both their adrenal glands removed for Cushing's disease may develop Nelson's syndrome. In this disorder, a pituitary tumor develops, producing large amounts of corticotropin and other hormones that stimulate melanocytes, leading to darkening of the skin. The enlarging pituitary tumor may compress nearby structures in the brain, producing headaches and defects in vision. Some experts believe that this may be prevented, at least in some people, by radiation therapy to the pituitary gland. If necessary, Nelson's syndrome can be treated with radiation or surgical removal of the pituitary gland."
( http://www.merck.com/mrkshared/mmanual_home2/sb/sb164_2.jsp )

Answer 4

Nelson syndrome is a disorder characterized by abnormal hormone secretion, enlargement of the pituitary gland (hypophysis), and the development of large and invasive growths known as adenomas.

Answer 5

To better understand Nelson syndrome try this web site, the medical doctors on this site will put it in lays terms for better comprehension.
http://www.WebMD.com