i want know about the history of aspirin?

Answer 1

ASPIRIN -

Aspirin is one of the safest and least expensive pain relievers on the marketplace. While other pain relievers were discovered and manufactured before aspirin, they only gained acceptance as over-the-counter drugs in Europe and the United States after aspirin's success at the turn of the twentieth century.

HISTORY OF ASPIRIN-

The compound from which the active ingredient in aspirin was first derived, salicylic acid, was found in the bark of a willow tree in 1763 by Reverend Edmund Stone of Chipping-Norton, England. (The bark from the willow tree—Salix Alba—contains high levels of salicin, the glycoside of salicylic acid.) Earlier accounts indicate that Hippocrates of ancient Greece used willow leaves for the same purpose—to reduce fever and relieve the aches of a variety of illnesses.

During the 1800s, various scientists extracted salicylic acid from willow bark and produced the compound synthetically. Then, in 1853, French chemist Charles F. Gerhardt synthesized a primitive form of aspirin, a derivative of salicylic acid. In 1897 Felix Hoffmann, a German chemist working at the Bayer division of I.G. Farber, discovered a better method for synthesizing the drug. Though sometimes Hoffmann is improperly given credit for the discovery of aspirin, he did understand that aspirin was an effective pain reliever that did not have the side effects of salicylic acid (it burned throats and upset stomachs).

Bayer marketed aspirin beginning in 1899 and dominated the production of pain relievers until after World War I, when Sterling Drug bought German-owned Bayer's New York operations. Today, "Aspirin" is a registered trademark of Bayer in many countries around the world, but in the United States and the United Kingdom aspirin is simply the common name for acetylsalicylic acid.

The manufacture of aspirin has paralleled advancements in pharmaceutical manufacturing as a whole, with significant mechanization occurring during the early twentieth century. Now, the manufacture of aspirin is highly automated and, in certain pharmaceutical companies, completely computerized.

While the aspirin production process varies between pharmaceutical companies, dosage forms and amounts, the process is not as complex as the process for many other drugs. In particular, the production of hard aspirin tablets requires only four ingredients: the active ingredient (acetylsalicylic acid), corn starch, water, and a lubricant...

Answer 2

When Was The Aspirin Invented

Answer 3

The active ingredient was first mentioned as a pain killer made from willow bark in the fifth century BC. The buffered form created Aspirin in 1897.

The rest of the story is on Wikipedia. Follow the link.

Answer 4

Aspirin (acetylsalicylic acid) is derived from Willow bark. The Native American people made a tea of the bark,and used it to treat fevers and arthritis. It became known to American colonists,and then to Europeans. In the late 1890's ,it was extracted and refined by a German chemist( H. Dreser ) into what we now know as the modern form of this anti-inflammatory medication.

Answer 5

Felix Hofman, a 29 year old chemist who worked for the German company Bayer invented aspirin in April 1879. By 1940 it was the best selling painkiller in the world.

Answer 6

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Aspirin or acetylsalicylic acid, is a derivative of salicylic acid that is a mild, nonnarcotic analgesic useful in the relief of headache and muscle and joint aches. The drug works by inhibiting the production of prostaglandins, body chemicals that are necessary for blood clotting and which also sensitize nerve endings to pain.

The father of modern medicine was Hippocrates, who lived sometime between 460 B.C and 377 B.C. Hippocrates was left historical records of pain relief treatments, including the use of powder made from the bark and leaves of the willow tree to help heal headaches, pains and fevers.

By 1829, scientists discovered that it was the compound called salicin in willow plants which gave you the pain relief.

According to "From A Miracle Drug" written by Sophie Jourdier for the Royal Society of Chemistry: "It was not long before the active ingredient in willow bark was isolated; in 1828, Johann Buchner, professor of pharmacy at the University of Munich, isolated a tiny amount of bitter tasting yellow, needle-like crystals, which he called salicin. Two Italians, Brugnatelli and Fontana, had in fact already obtained salicin in 1826, but in a highly impure form. By 1829, [French chemist] Henri Leroux had improved the extraction procedure to obtain about 30g from 1.5kg of bark. In 1838, Raffaele Piria [an Italian chemist] then working at the Sorbonne in Paris, split salicin into a sugar and an aromatic component (salicylaldehyde) and converted the latter, by hydrolysis and oxidation, to an acid of crystallised colourless needles, which he named salicylic acid."

Henri Leroux had extracted salicin, in crystalline form for the first time, and Raffaele Piria succeeded in obtaining the salicylic acid in its pure state.

The problem was that salicylic acid was tough on stomachs and a means of 'buffering' the compound was searched for. The first person to do so was a French chemist named Charles Frederic Gerhardt. In 1853, Gerhardt neutralized salicylic acid by buffering it with sodium (sodium salicylate) and acetyl chloride, creating acetylsalicylic acid. Gerhardt's product worked but he had no desire to market it and abandoned his discovery.

In 1899, a German chemist named Felix Hoffmann, who worked for a German company called Bayer, rediscovered Gerhardt's formula. Felix Hoffmann made some of the formula and gave it to his father who was suffering from the pain of arthritis. With good results, Felix Hoffmann then convinced Bayer to market the new wonder drug. Aspirin was patented on March 6, 1889.

The folks at Bayer came up with the name Aspirin, it comes from the 'A" in acetyl chloride, the "spir" in spiraea ulmaria (the plant they derived the salicylic acid from) and the 'in' was a then familiar name ending for medicines.

Aspirin was first sold as a powder. In 1915, the first Aspirin tablets were made. Interestingly, Aspirin ® and Heroin ® were once trademarks belonging to Bayer. After Germany lost World War I, Bayer was forced to give up both trademarks as part of the Treaty of Versailles in 1919.

Answer 7

http://en.wikipedia.org/wiki/Aspirin

go under discovery

Answer 8

...go to Google... type PDR and look it up.. Acida-salic-silic-acid. Great stuff)