Which medication converts to phenobarbital in the bloodstream? Besides phenobarbital.?

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Which medication converts to phenobarbital in the bloodstream? Besides phenobarbital.?

2007-03-12 13:03:59 · 2 answers · asked by Jeremy M 1 in Science & Mathematics ➔ Medicine

2 answers

I'm not sure what you're referring to, but phenobarbital is metabolized in the liver by the P450 enzyme system.

2007-03-12 13:16:58 · answer #1 · answered by citizen insane 5 · 0⤊ 0⤋

Phenobarbital is metabolized by the liver, mainly through hydroxylation and glucuronidation, and induces many isozymes of the cytochrome P450 system.
Cytochrome P450 2B6 (CYP2B6) is specifically induced by phenobarbital via the CAR/RXR nuclear receptor heterodimer. It is excreted primarily by the kidneys. " than U wiki and confirmed by usmle

2014-12-27 09:33:46 · answer #2 · answered by kiki 1 · 0⤊ 0⤋