What is the role of crtinine in fatty acid oxydation?

Answer 1

Do you mean carnitine? If you do, read below

Fatty acids must be activated in the cytoplasm before being oxidized in the mitochondria. Activation is catalyzed by fatty acyl-CoA ligase (also called acyl-CoA synthetase or thiokinase). The net result of this activation process is the consumption of 2 molar equivalents of ATP.

Fatty acid + ATP + CoA -------> Acyl-CoA + PPi + AMP

Oxidation of fatty acids occurs in the mitochondria. The transport of fatty acyl-CoA into the mitochondria is accomplished via an acyl-carnitine intermediate, which itself is generated by the action of carnitine acyltransferase I, an enzyme that resides in the outer mitochondrial membrane. The acyl-carnitine molecule then is transported into the mitochondria where carnitine acyltransferase II catalyzes the regeneration of the fatty acyl-CoA molecule. Following activation to a fatty-CoA, the CoA is exchanged for carnitine by carnitine-palmitoyltransferase I. The fatty-carnitine is then transported to the inside of the mitochondrion where a reversal exchange takes place through the action of carnitine-palmitoyltransferase II. Once inside the mitochondrion the fatty-CoA is a substrate for the beta-oxidation machinery (which is called so since it occurs through the sequential removal of 2-carbon units by oxidation at the beta-carbon position of the fatty acyl-CoA molecule).

Answer 2

See Impaired fatty acid oxidation in propofol infusion syndrome.

The Lancet, Volume 357, Issue 9256, Pages 606-607

A. Wolf, P. Weir, P. Segar, J. Stone, J. Shield

Answer 3

Carnitine, also known as L-carnitine (levocarnitine) is a quaternary ammonium compound synthesized from the amino acids lysine and methionine and is responsible for the transport of fatty acids from the cytosol( is the internal fluid of the cell, and a portion of cell metabolism occurs here) into the mitochondria(they convert food molecules into energy in the form of ATP via the process of oxidative phosphorylation,therfore are called powerhouse of cell) It is often sold as a nutritional supplement.

Answer 4

Do you mean carnitine? If you do, read below

Fatty acids must be activated in the cytoplasm before being oxidized in the mitochondria. Activation is catalyzed by fatty acyl-CoA ligase (also called acyl-CoA synthetase or thiokinase). The net result of this activation process is the consumption of 2 molar equivalents of ATP.

Fatty acid + ATP + CoA -------> Acyl-CoA + PPi + AMP

Oxidation of fatty acids occurs in the mitochondria. The transport of fatty acyl-CoA into the mitochondria is accomplished via an acyl-carnitine intermediate, which itself is generated by the action of carnitine acyltransferase I, an enzyme that resides in the outer mitochondrial membrane. The acyl-carnitine molecule then is transported into the mitochondria where carnitine acyltransferase II catalyzes the regeneration of the fatty acyl-CoA molecule. Following activation to a fatty-CoA, the CoA is exchanged for carnitine by carnitine-palmitoyltransferase I. The fatty-carnitine is then transported to the inside of the mitochondrion where a reversal exchange takes place through the action of carnitine-palmitoyltransferase II. Once inside the mitochondrion the fatty-CoA is a substrate for the beta-oxidation machinery (which is called so since it occurs through the sequential removal of 2-carbon units by oxidation at the beta-carbon position of the fatty acyl-CoA molecule).