discuss zymogen activation to enzymes?

Question

discuss zymogen activation to enzymes?

Answer 1

A zymogen is an enzyme that is released in an inactive form, to prevent inapproprate activity, and must be activated through change in its structural conformation, usually by a change in pH, or through the action of antoher enzyme.

A prominent example of this is pepsinogen, a zymogen released by chief cells in the stomach. It is inactive until the acidic pH of hydrochloric acid released by parietal cells of the stomach activate pepsinogen to pepsin (which digests many proteins) -- the purpose of this is to prevent pepsin's digestive activity at other sites in the body, which would clearly be harmful. Thus, pH-dependence strictly limits its activity to the stomach, and thereby protects other organs.

Answer 2

Check out this webpage which will answer your question in detail:
http://content.febsjournal.org/cgi/content/full/272/1/85