What diseases can cause a deficiency of B12 and/or Folic acid in Humans?

Question

Thank you to all the answerers.

Answer 1

pernicious anemia for one..a bleed somewhere in your bowels or other organs...a poor diet eith no redmeat or calcium or some blood disorders like leukemia

Answer 2

Over time, a deficiency in either B12 or folate also known as Folic Acid can lead to macrocytic anemia, a condition characterized by the production of fewer, but larger red blood cells and a decreased ability to carry oxygen. Patients who have this condition may tire easily, be weak, and be short of breath. A deficiency in B12 can also result in varying degrees of neuropathy, nerve damage that can cause tingling and numbness in the patient’s hands and feet and mental changes such as confusion, irritability, and depression.

Answer 3

Absence of intrinsic factor itself is the most common cause of vitamin B-12 deficiency. Intrinsic factor is produced by cells in the stomach. In adults, the inability to make intrinsic factor can be the result of chronic gastritis or the result of surgery to remove the stomach. The onset of the disease is slow and may take decades.

Pernicious anemia is caused by a lack of intrinsic factor, a substance needed to absorb vitamin B-12 from the gastrointestinal tract. Vitamin B-12 is necessary for the formation of red blood cells.

Anemia is a condition where red blood cells are not providing adequate oxygen to body tissues.

Other causes of low levels of intrinsic factor include atrophic gastric mucosa, autoimmunity against gastric parietal cells, and autoimmunity against intrinsic factor.

On the other hand, not getting enough folic acid results in a form of megaloblastic anemia. Megaloblastic anemia is a blood disorder characterized by anemia, with red blood cells that are larger than normal.

Folic acid is especially essential for pregnant women. If women do not take in enough folic acid before conception and during pregnancy, there is an increased risk that the baby will have severe birth defects of the brain and spinal cord, known as neural tube defects such as spina bifida. Pregnant women who do not consume enough of the vitamin also have an increased chance of giving birth prematurely or of having low birth weight babies.

Answer 4

Deficiency

The usual daily intake in the Western diet is 5-7 µg (Food and Drug Administration (FDA) Daily Value [7]); the daily requirement is 1-2 µg. B12 is mostly absorbed in the terminal ileum. The production of intrinsic factor in the parietal cells of the stomach is vital to absorption of this vitamin in terminal ileum. Megaloblastic anemia can result from inadequate intake of B12, inadequate production of intrinsic factor (pernicious anemia), disorders of the terminal ileum resulting in malabsorption, or by competition for available B12 (such as fish tapeworms or bacteria present in blind loop syndrome).

Metformin can also be associated with vitamin B12 deficiency[8]. Metformin is a common drug-induced cause of B12 deficiency. It is felt that metformin inhibits calcium-dependent ileal absorption of the B12-intrinsic factor complex.

Important limitations of this study include its retrospective design, lack of information about neurologic symptoms, and lack of a confirmatory biochemical test for B12 deficiency such as methylmalonic acid measurements. Nevertheless, the findings emphasize that neurologists should consider the possibility of B12 deficiency in diabetic patients with neurologic symptoms while taking metformin.

B12 deficiency is manifested primarily by anemia and macrocytosis; other cell lines such as white blood cells and platelets are often also low. Bone marrow examination may show megaloblastic hemopoiesis. Serum homocysteine and methylmalonic acid levels are also high in B12 deficiency and can be helpful if the diagnosis is unclear.

Neurological signs of B12 deficiency, which can occur without accompanying hematologic abnormalities, include demyelination and irreversible nerve cell death. Symptoms include numbness or tingling of the extremities and an ataxic gait, a syndrome known as subacute combined degeneration of the cord.

The American Psychiatric Association's American Journal of Psychiatry has published studies showing a relationship between depression levels and deficient B12 blood levels in elderly people in 2000 [9] and 2002 [10].

Answer 5

Most normally Vitamin B12 (cobalamin) deficiency is a common cause of macrocytic anemia. Talk to your doctor, they may want you to try and eat more red meat, beef/calf liver would be ideal. Multi vitamin would be good also. For the folic acid drink more OJ. Good luck

Answer 6

Any and all, as they're all more or less symptomatic conditions of the same disease of weakness, stupidity, and misfortune. Assert; What's the true cause, and what can your body do to heal itself? B12 recycles itself in the body; This is why only very small amounts are technically required for survival, and these amounts come initially from mother's milk from that species. Most human beings either don't get enough or are in need of constant supply, and most humans have some sort of health condition or 'disease' (as it would be labeled by the money-makers of America).

Answer 7

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Answer 8

Anemia

Answer 9

Ask your doctor about an exercise routine. Regular exercise, such as walking three times a week, may reduce neuropathy pain, improve your muscle strength and help control blood sugar levels. Gentle routines such as yoga and tai chi might also help.

Answer 10

I hope this website helps answer your question.
http://www.wrongdiagnosis.com/v/vitamin_b12_deficiency/causes.htm