Why should pyruvic acid be converted into acetyl coA and then unite with oxaloacetate to yield energy?

Question

If glucose is to provide energy, then why should it split first into two 3-carbon compound and then to 2-carbon compound and why does the latter have to unite with a 4-carbon compound to yield energy?

Acetyl coA is joined to oxaloacetate. Why should Acetyl coA be joined to a 4-carbon compound to release energy? Why is oxaloacetate so suitable for joining(condensation)?

Answer 1

Well, all the processes, including the need of acetyl CoA and oxaloacetate, are a necessity. Why? This is HOW the mechanism works! In order to have a citric cycle, you must have citrate. If you need citrate, then you have to use oxaloacetate and acetyl CoA....This is how it works. If i were to ask you why you need a solar panel to generate energy instead of just using it as it is, how would you answer? We use solar panel because it is the WAY to generate solar power. Same goes to your question...glucose cannot be used just like that because it requires a way...so, it has chosen the way you are reading now.

Meanwhile, all the splitting seems futile and nonsense as in the end, a six carbon citrate still exists, similar to the 6 carbon glucose. So wats the point??? Well, the splitting gives up more ATP [and hence energy] and it also ensures the Kreb cycle to run and yield energy.

Answer 2

it is necessary to convert pyruvic acid to acetyl coA as acetyl coA is required for TCA cycle which yields 4 ATP. and accumulation of pyruvic acid causes certain diseases. so pyruvic acid must be converted t oacetyl co A

Answer 3

energy exists in bond of atoms, then for release of energy it should split.
the end of glycolis pathway is pyruvic acid so that for release higher energy it should split in TCA cycle.

Answer 4

Look up about the citric cycle in wikipedia.

Answer 5

And you were almost swallowed by ur mama...