how does lidocaine work?

Question

what is the chemistry concept behind the effects of lidocaine?

Answer 1

I'm a dentist.

Lidocaine, like other "caines", is a membrane stabilizer. Specifically, it blocks the voltage-gated sodium channels at the nodes of Ranvier that allow the influx of sodium when the nerve reaches the threshold voltage (negative 40 millivolts, if memory serves), thus preventing an action potential. No action potential means no nerve impulse.

Because lidocaine blocks these voltage-gated sodium channels, which are located elsewhere in the body where action potentials exist (such as cardiac muscle), it serves as an anti-arrhythmic.

That's not all, though. Inject lidocaine next to a motor nerve, and it will create temporary paralysis.

When given in too high a dose, lidocaine's toxic effects are predictable: convulsions/CNS excitation followed by CNS depression, bradycardia, and eventually cardiovascular collapse.

Lidocaine is an amide, and is metabolized in the liver. It's active at the nerve in its ionized form, however, it reaches its target better in its non-ionized form. Beyond that, I don't know a heck of a lot about the chemistry.

Answer 2

Lidocaine alters depolarization in neurons, by blocking the fast sodium (Na+) channels in the cell membrane. With sufficient blockade, the membrane will not depolarise and so not transmit an action potential, leading to its anesthetic effects.

Answer 3

for IV or IM injection "suppresses automaticity and spontaneous depolarization of the ventricles during distole by altering the flux of sodium ions across cell membranes with little or not effect on heart rate."

for local: produces local anesthesia by inhibiting transport of ions across neuronal membranes, thereby preventing initiation and conduction of normal nerve impulses."

Is that too bio based for what you are looking for?

Answer 4

What Does Lidocaine Do

Answer 5

Cheap Online Mall >>===> http://lidocaine3.4gw.pw/8pl1u