if the dose of a medicine is changed to x times the original value then how will the half-life change?

Question

To be more specific if a patient takes 0.5mg of clonezepam what is the half-life.And when he takes 0.25mg of clonezepam what is the halflife.

Also when he takes 1mg,2mg,etc what is the half life.

It would also help if i can get a formula that can give me the relation between old halflife & new halflife when the dose is changed.

Answer 1

The half-life is a function of the molecule, the drug formulation and, to a lesser degree, the patient's metabolic profile. The half-life therefore does not change with the dose. What changes is the blood level at half-life, which will be a direct function of the dose multiple(x).

Answer 2

i did no longer think of the a million/2 existence replaced once you replaced the dose if there are first degree kinetics (maximum drugs). consequently the comments I even have considered on the information superhighway say that the a million/2 existence is approximately 35 hours (watching the affected person).

Answer 3

The half-life does not change. The duration of action and blood levels will change.

The half-life of clonazepam is 30-40 hours, which means half of the drug will be gone in that time. If you give twice as much (assuming that it is all absorbed), you will have blood levels twice as high.

The duration does not double, but increases by one half-life each time you double the dose.

Hope that helps.

Answer 4

Hal life of any medicine is constant