what is the major protein-splitting enzyme in pancreatin?

Answer 1

i believe this is the protein - Trypsin is produced in the pancreas in the form of inactive zymogen, trypsinogen. It is then secreted into the small intestine, where the enzyme enterokinase activates it into trypsin by proteolytic cleavage. The resulting trypsins themselves activate more trypsinogens (autocatalysis), so only a small amount of enterokinase is necessary to start the reaction. This activation mechanism is common for most serine proteases, and serves to prevent autodigestion of the pancreas.

Answer 2

Not sure what you are asking. But the pancrease makes three enzymes. Amylayse - Breaks Starch; Lipase - Breaks Lipids or Fats; Trypsin - To break proteins

Hope this helps....