for example Dextromethorphan always is HBr or Pseudoephedrine is always HCL or Codeine is either sulfate or phosphate. is it for time release or what. does one salt dissolve faster or does one last longer is it for that (duration)?
2007-02-08 05:59:32 · 5 answers · asked by Goldfish 2 in Science & Mathematics ➔ Medicine
If I remember correctly, it has to do with chemical stability. For example Pseudoephedrine (the chemical) may be very unstable itself. But if a hydrochloride molecule is added on, it may increase it's stability and solubility in certain compounds.
2007-02-08 08:17:53 · answer #1 · answered by mom2pnuts 3 · 0⤊ 0⤋
the answers on top are correct but also it depends where the absorption of the drug is intended to take place!
a good example as you said, pseudoephedrines is in HCl.
water soluble drugs are easily absorbed in thier unionised form!!
Alkali Drugs are not absorbed in the stomoch because they become ionised in the acidic condition, but they do get absorbed in the S.intestine where they remain in thier unionised form, because the S.intestine is alkali and does not Ionise the Drug,
in the stomach the drug would be would be acidic and in the s.intestine it would be alkali,
it all depends where the drug is ment to be absorbed!!.
hope this helps!!
2007-02-15 17:44:17 · answer #2 · answered by toxic adrenaline 2 · 0⤊ 0⤋
It is usually a function of solubility. A salt with a higher solubility is often chosen to optimize bioavailability. Sometimes it is a matter of preparative chemistry: one particular salt may be easier or cheaper to isolate.
2007-02-08 16:15:30 · answer #3 · answered by Jerry P 6 · 0⤊ 0⤋
reactivity, solubility, reliability, upset stomach prevention
2007-02-15 01:39:06 · answer #4 · answered by Anonymous · 0⤊ 0⤋
how come more salt dont have medication
2007-02-15 22:24:37 · answer #5 · answered by ashkicker420 3 · 0⤊ 0⤋