How might excessively high body temperature or acidosis interfere with enzyme activity?

Answer 1

Well, both would probably inhibit enzyme activity, depending on the enzyme. Moderate increases in temperature generally increase enzymatic activity because it lowers energy of activation, but excessively high temperature denatures proteins.

Acidosis would likely cause proteins to be inactive as well, since most enzymes require a strict pH range (to produce the appropriate charges on side chains, for optimal binding in the enzymatic active site) in order to function, and acidosis obviously prevents that -- unless you're talking about a gastric digestive enzyme produced to function at low pH, in which case its activity would not be hindered.