Mirtazapine and increased sex drive?

Question

I've heard Mirtazapine increases sex drive. Is that true?

Answer 1

Mirtazapine is an antidepressant introduced by Organon International in 1996 used for the treatment of mild to severe depression. Although Mirtazapine has a tetracyclic chemical structure the pharmaceutical company have chosen to promote the drug using the acronym noradrenergic and specific serotonergic antidepressant (NaSSA), although there is only modest evidence from their research department to support its claimed effects. Indeed, recent work by researchers independent of Organon International has failed to replicate much of the original data. The difference in receptor profile from the 'parent' drug, mianserin, appears to be non-existent, at least with respect to those properties that are hypothesised to be relevant . Due to its unique pharmacologic profile, mirtazapine is virtually devoid of anticholinergic effects, serotonin-related side effects, and adrenolytic effects (orthostatic hypotension and sexual dysfunction). As such it may be preferable to SSRIs in some patients. Mirtazapine is relatively safe if an overdose is taken. It does not increase sex drive. I hope this helps.

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Answer 2

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