how does cymbalta and ultram react to each other?

Question

I take these two medications and both trigger nerve pain and i was told that they react harshly to each other and I want to know how.
Cymbalta is a antidepressant and ultram is a pain med also known as tramadol.

Answer 1

the combiantion may increase tramodol levels, , may increase the risk of serotonin syndrome and seizures. The mechanism is inhibition of matabolism of Ultram and combination effects, good luck