Does Lewy Bodies have a genetic component?

Answer 1

Lewy Bodies are seen microscopically in brain tissues and are usually associated with Parkinson’s disease. Lewy bodies are tangles of fibers inside a neuron cell body that stain positive with ubiquitin and alpha synuclein. In Parkinson’s disease, these histological anomalies are usually found in the substantia nigra, basal nucleus of Meynert, cingulated gyrus, and the parahippocampal gyrus.

While there is no evidence of a genetic component, Parkinson’s disease can show autosomal dominant inheritance.

Answer 2

Lewy bodies are abnormal aggregates of protein that develop inside nerve cells.

They are identified under the microscope when histology is performed on the brain. They appear as spherical masses that displace other cell components

A classical Lewy body is an eosinophilic cytoplasmic inclusion that consists of a dense core surrounded by a halo of 10-nm wide radiating fibrils, the primary structural component of which is alpha-synuclein. In contrast, a cortical Lewy body is less well-defined and lacks the halo. Nonetheless, it is still made up of alpha-synuclein fibrils.

A Lewy body is composed of the protein alpha-synuclein associated with other proteins such as ubiquitin, neurofilament protein, and alpha B crystallin. It is believed that Lewy bodies represent an aggresomal response in the cell.

Answer 3

no- they're just proteins. there's no DNA in them.