Grapefruit juice has been found to interact with many drugs taken orally. Compounds in the juice including bergamottin, dihydroxybergamottin, and some flavonoids such as naringin affect the activity of certain intestinal enzymes including CYP3A4 and CYP1A2.
These cytochrome P450 enzymes, which metabolize many drugs, are inhibited by grapefruit juice. As a result, serum drug concentrations increase and may become toxic. This is particularly dangerous when the drug in question has a low therapeutic index, so that a small increase in blood concentration can be the difference between therapeutic success and toxicity. Grapefruit juice only inhibits the enzyme within the intestines, not elsewhere (the liver, for instance). Therefore, it does not affect injected drugs. The degree of the effect varies widely between individuals and between samples of juice, therefore it cannot be accounted for a priori.
Drugs that may be affected include midazolam, ciclosporin, lovastatin, simvastatin, pravastatin, felodipine, sildenafil (Viagra) and caffeine, as well as a number of antihistamines including astemizole and terfenadine.
An easy way to tell if a medication may be affected by grapefruit juice is by researching whether another known CYP3A4 inhibitor drug is already contraindicated with the drug in question. Examples of such known CYP3A4 inhibitors include cisapride (Propulsid), erythromycin, itraconazole (Sporanox), ketoconazole (Nizoral), and mibefradil (Posicor).
The flavonoid existing in highest concentration in grapefruit juice is naringin, which in humans is metabolized to naringenin. Other flavonoids exist in grapefruit juice in lower concentrations as well. Orange juice does not contain naringin in as high a concentration, instead containing hesperetin. It is sometimes recommended as a substitute. Juice of limes and Seville oranges can also inhibit drug metabolism, however, as can apple juice with some drugs
2007-01-31 23:02:38
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answer #1
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answered by Johny0555 3
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Grapefruit Juice contains citric acid, it's not always good for people with certain conditions.
Red Grape Juice is great, but if you're taking Vitamins' its probably pointless drinking red grape juice. Stick to wine or a good pint of ALE!
2007-02-01 07:10:59
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answer #2
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answered by usha4pillai 2
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Grapefruit Juice will cause problems with some prescription medication. You shouldn't have any problem with grape juice but it's always better to take medication (vitamins or medications) with plenty of fresh water. (I have a problem with drinking water early in the morning, so I have to take my medications later in the day, especially vitamins).
2007-02-01 07:04:44
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answer #3
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answered by i have no idea 6
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acid in grape juice with a pill, will case you to have ulcers. See
after you take it, do you get heart burn, heart burn is a sign, somethings going on in your stomach that has caused it to bubble and make your stomach acid rise. Its not good. Drink water,
Besides that, if your not drinking water with your pills, your blood is so thick, like paste your pill does worse things to your stomach and liver you have no idea. Water, lots of it a day, vitamins by pill your only getting 10% of it in you any way, the rest went to wast,
make sure your stomach has something like bread, and grape juice is good, but your stomach is going to fail you later down the line. don't abuse your stomach and liver over something as simple as water. That pill goes into the blood stream to help you, but if the blood is not flowing like water, it won't help you at all, cause all your blood is wanting to do is clot. That is why blood clots are formed. Drink water. Lots of it, 4 bottles a day. Help those Vitamin pills help you.
2007-02-01 07:36:36
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answer #4
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answered by Faith Walker 4
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I almost died by doing that so be careful. I spent eight days in the hospital and had my right leg amputated. The loss of blood was also a big complication. I still cannot use my right arm and have no feeling left in most of my extremities. Several teeth are now missing and I ache all over. Where you choose to drink it is most vital. ( I was fixing tire on interstate when i took a break and was drinking my grape juice. the semi driver said he never saw me)
2007-02-01 07:07:30
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answer #5
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answered by Anonymous
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Vitamin pills are usually not considered as drugs but rather natural ingredients. Grape juice could be good I think. My physical trainer advised me that the best way to consume my creatin is by dissolving it with grape juice.
2007-02-01 07:03:41
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answer #6
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answered by Claude 6
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use water, I mean why ask the question? if you like grape juice then drink it, but when taking medication or vitamins it should be with plenty of fresh water.
2007-02-01 09:17:04
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answer #7
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answered by thevoice 4
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any vitamin tablets or other medicines are best with full glass of water and no less.Much better if u drink more at the same time if not drink after 1 hour.but drink as much water as u can.Never take any tablets with tea or coffee
All fruit juices have citric acid and it is better not to mix as it is safe not to mix.Eat much grapes as you can good for the heart and respiratory system.
2007-02-01 07:16:06
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answer #8
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answered by Bikram rai 6
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HAHA!do you love grape juice that much?i think you can.cos you said that you want to drink RED GRAPE JUICE with your vit c.but you only said that GRAPEFRUIT JUICE should be avoided.both juices are different!
2007-02-01 10:17:59
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answer #9
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answered by flabberina 1
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2014-08-08 03:50:53
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answer #10
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answered by Anonymous
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