what is the mechanism of action of bisphenol A in the body?

Answer 1

BPA has been known to leach from plastics which are cleaned with harsh detergents or used to contain acidic or high temperature liquids. The chemical is found in most people who live in developed countries at very low concentrations.

BPA can activate estrogen receptors leading to similar physiological effects as the body's own estrogens. The first evidence of BPA's estrogenicity came from experiments in the 1930s in which it was fed to ovariectomised rats. Some hormone disrupting effects in studies on animals and human cancer cells have been shown to occur at levels as low as 2-5 ppb (parts per billion). It has been claimed that these effects lead to health problems such as, in men, lowered sperm count and infertile sperm.
Belcher and coworkers demonstrated that even very low levels of BPA can disrupt neural development in the fetus (rat)

With funding from the National Institutes of Health, Vom Saal and Welshons have shifted their research efforts toward an explanation of how and why BPA has such a powerful effect on an animal’s endocrine system and reproductive organs. They have begun the process of identifying the molecular mechanisms at work when the hormone enters an animal’s cells.