can somebody help me with my report in microbiology about tetanus? pls explain the excerpt below..?

Question

"In general the further the injury site is from the central nervous system, the longer the incubation period. The shorter the incubation period, the higher the chance of death"

your answer will be of great help to me. thanks

Answer 1

"Clostridium tetani", an Anaerobic Spore-Former, Produces an A-B Toxin, the A Portion Travels up Motor Axons, to the Cell Body (?!), Ultimately Inhibiting the Fusion of Glycine-Containing Vesicles of Motor Inhibitory Neurons in the Spinal Cord, if I Remember Correctly, Coded for by a Lysogenic Phage and Elaborated During Sporulation.

Answer 2

Clostridium tetani releases a potent neurotoxin that, as the name implies, acts exclusively on the central nervous system. Therefore, the farther the wound is from the CNS, the less toxin manages to make it to the CNS, which in turns leads to a less severe poisoning. It is important to remember that tetanus is not an infection but instead a toxicity resulting from an infection. The shorter incubation period implies that more toxin is reaching the CNS making it more difficult for the body to overcome the toxin. Also worthy of note is that antibodies against the toxin take time to form, and the slower the progression of the disease, the more opportunity the body has to mount an effective response. Tetanus is nasty, but, fortunately, in the United States there are fewer than 10 cases per year thanks to zealous vaccination programs.

Answer 3

Incubation period is that period between getting the infection (usually shortly after one gets wounded) and just before the manifestation of the disease's symptoms. Clostridium tetani produces a powerful neurotoxin. That toxin travels through the nerves. The nearer the infected wounds and nerves are to the brain, the shorter the incubation period will be (short travel time), and the higher the chance that the person will die from tetanus. Once the neurotoxin reaches the brain, its effects will be disastrous. The early administration of tetanus antitoxin, early in the incubation period, is therefore a must if the person is to survive.