what is the role of nimodipine in subarachnoid haemorrhage?

Question

Nimodipine is a calcium channel blocker.

Answer 1

Subarachnoid hemorrhage is a relatively uncommon cause of headache. Most patients with headache who visit Emergency Departments (EDs) or physicians' offices have more benign tension‑type, sinus-related or migraine headaches. Among all patients with headache who presented to EDs, retrospective studies have found that approximately 1 to 4 percent had SAH. Prospective studies found that if only patients with the "worst headache" of their lives and a normal neurologic exam were considered, 12‑33% percent of such patients had SAH.(1) This proportion increased to 25% when patients whose examinations were abnormal were included. Of the 30,000 patients found to have nontraumatic SAH in the United States annually, roughly 80% have ruptured saccular aneurysms causing acute bleeding into the subarachnoid space primarily at the base of the brain. Among the remaining 20%, about half have nonaneurysmal peri-mesencephalic hemorrhages.

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Answer 2

Calcium channel blockers (calcium antagonists)
Calcium antagonists reduce the amount of calcium entering the muscle cells of the arteries, causing them to relax.
This leads to the blood flow to the heart increasing and reducing the work the heart has to do to pump blood around the body.
Types of the drug include nifedipine, diltiazem and verapamil.
Side-effects include flushing, headache, dizziness, fainting, swelling of the ankles and stomach and gastro-intestinal problems.
Nimodipine is used to prevent and treat problems caused by a burst blood vessel around the brain (also known as a ruptured aneurysm or subarachnoid hemorrhage).
(MedlinePlus)
Nimodipine (marketed by Bayer as Nimotop®) is a dihydropyridine calcium channel blocker originally developed for the treatment of high blood pressure. It is not frequently used for this indication, but has shown good results in preventing a major complication of subarachnoid hemorrhage (a form of cerebral hemorrhage) termed vasospasm; this is now the main use of nimodipine.(Wikipedia)
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