Wiskott - Aldrich Syndrome???

Question

hey, well, I think I have this right, I'm just making sure.

Mr. Silvia's sister had a child with Wiskott - Aldrich Syndrome. Mr. Silvia does not have it. Mrs. Silvia has no history of the disorder in her family.

WAS is sex linked recessive and so only males have it but females can be carriers.

Is it possible for Mr. and Mrs. Silvia to have a child with WAS?

Answer 1

Yes.
Since it is sex linked recessive and females are carriers we know Mr is not contributing.
However just because Mrs. doesn't have history of it in her family does not mean she can't be a carrier. Perhaps there is a long line of carrier females. Females are carriers because they have 2 X chromosomes. The abnormal gene since it is recessive does not show up as disease because she has a normal gene on the other X to make up for it.
They can have an affected male child. Mr. will give his son a Y chromosome and Mrs will give him the abnormal X. (They could have a normal son if Mrs passed down a normal X)