HIV & AIDS Biology Question?

Question

How & Why does the HIV attacks the white blood cells in human? Pls give a detailed explaination because my lecturer is quite fussy. =) thnx.

ps: cant seem to find any long explainations online.

Answer 1

Keep looking.
http://www.avert.org/evidence.htm
http://www.aegis.com/topics/basics/hivandaids.html
http://hivinsite.ucsf.edu/hiv?page=basics-00-03
http://www.webmd.com/content/article/4/1680_50176.htm

Answer 2

It is a Autoimmune system disorder, there is no why in it's actions that is part of what it does because that is its own perpose.

How it works is it latches on to the cell and injects into the DNA inside, changing the purpose of the cell to produce more of the virus. Eventually the cell explodes unleashing the built up viruses to infect more cells. This leads to decreased numbers of active white blood cells and so a decreased immune system.

Answer 3

Human cloning or obtaining insulin through genetic engineering.

Answer 4

HIV uses homing to kill white blood cells
New HIV Model Shows Virus Doesn't Kill White Blood Cells, It Just Homes Them To Death

By Sally Pobojewski
Health System Public Relations
U-M scientist Denise Kirschner has developed a new mathematical model that shows how HIV—the virus that causes AIDS—slowly destroys its victim’s immune system by accelerating a normal process called homing, which diverts white blood cells from the bloodstream to the lymph system.

Increased understanding of the complex relationship between the HIV virus and the immune system is important, because it will help scientists develop more effective treatments for AIDS and suggest new targets for therapeutic drugs.

“This model indicates that the key to extending survival time for people with AIDS is to minimize the number of CD4 cells exposed to signals in the lymph system that lead to apoptosis or cell suicide,” says Miles W. Cloyd, professor of microbiology at the University of Texas Medical Branch at Galveston.

Developed in collaboration with G.F. Webb of Vanderbilt University, Kirschner’s model validates the homing theory of HIV progression, which was first proposed by Cloyd and his colleagues. Results from the model were published in the Aug. 1 issue of The Journal of AIDS.





Many scientists believe HIV destroys the immune system by attacking white blood cells called CD4 or helper T-cells in the bloodstream. But Kirschner and Cloyd maintain that HIV’s lethal action is much more subtle and indirect.



Their model shows that CD4 cells actually self-destruct in the lymph system. Death comes as a result of exposure to biochemical signals involved in the homing process, which trigger apoptosis or cell suicide.




“Previous HIV models have focused on what happens in the bloodstream, but the real action is in the lymph system,” says Kirschner, assistant professor of microbiology and immunology. “A very small percentage of cells dies from apoptosis on a daily basis, but over a seven-year period, it adds up to almost 100 percent.”

Results from the U-M model are consistent with what happens in people, according to Cloyd. Data from clinical studies with HIV-infected patients show that the population of uninfected CD4 cells in their blood falls to 15 percent of normal during a seven-year period.

When the HIV virus binds to a CD4 cell, one of three things can happen, according to Kirschner. First, the cell can be actively infected and turn into a cellular factory that produces more virus. Second, the immune cell can be latently infected; the virus gets inside the cell nucleus, but remains dormant. Third, and most common, the CD4 cell can be abortively infected. In this case, the virus enters the cell cytoplasm, but doesn’t enter the nucleus.

“When the HIV virus binds to a CD4 cell, the process activates a receptor molecule called L-selectin on the cell membrane, which signals the CD4 cell to home to the lymph system,” Kirschner explains. “If we could block that signal, we could preserve healthy CD4 cells.”

In future research, Kirschner plans to model the role of co-receptors involved in HIV binding to CD4 cells. The virulence of infection varies depending on the co-receptor chosen by the virus. She also plans to explore the immune response to HIV, and how different types of immune responses, known as TH1 or TH2 responses, determine disease progression.

“Miles Cloyd’s work has brought the concept of lymphocyte circulation, which was a hot topic in the 1970s, back into the scientific limelight,” she says. “There could be applications to many other diseases.”

Development of the mathematical model of HIV progression was funded by the National Heart, Lung and Blood Institute of the National Institutes of Health, the National Science Foundation and the American Foundation for AIDS Research.

How does HIV attack the immune system?





HIV is unique among viruses because it attacks the very heart of the immune system: the CD4 cell. By targeting that cell, the virus interrupts the entire immune response.