Conn's syndrome is overproduction of the mineralocorticoid hormone aldosterone by the adrenal glands. Aldosterone causes sodium and water retention and potassium excretion in the kidneys, leading to arterial hypertension (high blood pressure). It is a rare but recognised cause of nonessential hypertension. It is named after Dr Jerome W. Conn (1907-1981), the American endocrinologist who first described the condition in 1955. It is the most common form of primary Hyperaldosteronism.
[edit] Signs, symptoms and findings
Apart from high blood pressure, the symptoms may include muscle cramps and headaches (due to the low potassium), metabolic alkalosis (due to increased secretion of H+ ions by the kidney). The high pH of the blood makes calcium less available to the tissues and causes symptoms of hypocalcemia (low calcium levels).
It can be mimicked by liquorice ingestion (glycyrrhizin) and Liddle syndrome.
[edit] Diagnosis
Measuring aldosterone alone is not considered adequate to diagnose Conn's syndrome. Rather, both renin and aldosterone are measured, and the ratio is diagnostic. Usually, renin levels are suppressed, leading to a very low renin-aldosterone ratio (<0.05). This test is confounded by antihypertensive drugs, which have to be stopped up to 6 weeks.
If there is biochemic proof of hyperaldosteronism, CT scanning can confirm the presence of an adrenal adenoma.
[edit] Causes
The syndrome is due to:
adenoma (benign tumor, 50-60%)
hyperplasia of the adrenal gland (40-50%)
2007-01-18 14:27:41
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answer #1
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answered by cubcowboysgirl 5
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This Site Might Help You.
RE:
Can a body produce too much blood?
Well, im working on a story on a girl with a blood disorder of some kind. so, is it possible for the human body to produce too much blood? if so, what happens to the excess blood?
2015-08-10 08:10:47
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answer #2
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answered by Quintina 1
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blood cells are created in your bones and the old ones are destroyed and eliminated from you body. Too many cells can be produced if you have a bone marrow disease. it is also possible to have too great of a blood volume caused from too much fluid in the blood. This can happen with various hormone imbalances such as oversecretion of anti diuretic hormone.
2007-01-18 14:20:57
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answer #3
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answered by Lolly 3
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I don't know about too much blood. But your blood can become so thin that it comes out of your pores. It happens some times when people take too much blood thinner medication. Usually heart and cancer patients.
2007-01-18 14:12:08
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answer #4
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answered by Anonymous
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blood cells are formed in bone marrow in the long bones of the body femur for example
2016-03-19 07:42:29
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answer #5
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answered by ? 4
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yes. this can happen with if too much erytrhorpoetein is made, also there is a condition called polycythemia vera
http://www.nlm.nih.gov/medlineplus/ency/article/000589.htm
2007-01-18 14:11:01
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answer #6
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answered by Anna M 2
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