When an organism with recombinant DNA reproduces will the offspring have the original or hybrid DNA?

Question

Do you know?

Answer 1

Depends on the type of organism and method. If it is a bacterium and carries the recombinant DNA as a plasmid, all the cells derived from cell division of this bacteria will carry the plasmid.

If it is a transgenic animal (or plant) then it has the recombinant DNA on one of its chromosomes, and it will be inherited as any other gene. So if it is heterozygous for the transgen then half of its offspring will have it, if homozygous then all of them.

These are not all the possibilities (you can have recombinant viruses, etc), but the most common.

Answer 2

If we take a mammal as an example, the outcome of introducing foreign DNA into its genome will depend on what type of cells have been modified. If a researcher wants to create let's say a transgene mouse whose progeny will also inherit its DNA modification, then a recombinant DNA will be introduced into egg cells which are then implanted into surrogate mothers. If everything works, the babies will carry the modification in all cells of their body (including the germ-line). All their offsprings will thus be transgenic. This technique is commonly used in mice.

A different approach, which has been used in humans, is called somatic gene therapy. This technique focuses on a specific tissue of an adult organism. Some somatic cells are taken from the patient, made transgenic and reintroduced back into the patient. Alternatively, a naked recombinant DNA can be injected into the muscle tissue. Since only somatic cells are being modified, the individual's children will not inherit the altered DNA.

Answer 3

if its asexual reproduction, the hybrid DNA will only get reproduced

Answer 4

I can't tell you unless I know the method of reproduction.