What is the reaction between grapefruit and Medication ie: lipitor or high blood pressure pills?

Answer 1

Grapefruit juice causes increased levels of atorvastatin (Lipitor). It is metabolized by the same cytochrome P450 3A4 enzyme which will decrease the first pass effect in the liver and therefore increase lipitor concentrations that are in the blood stream.

If you are an avid grapefruit drinker and are concerned about not being able to drink it, don't be alarmed. If you were to drink or eat the same amount of grapefruit juice each day you would be able to maintain proper drug levels in your body. Just be sure to let you doctor know, so that when he prescribes the dose he doesn't give you too large of strength.

It is possible to have some grapefruit juice in the morning when you are taking your Lipitor (or other statin) in the evening. Just be sure to talk to your pharmacist or doctor beforehand.

Increased drug levels will increase side effects. Most notably is the rhabdomylysis (or increased muscle breakdown - it will feel like sore muscles), and this is bad.

I'm surprised that the MD posts that there is no consequence to taking grapefruit juice and lipitor. He should do some reading. It can be a very big concern, so don't take it lightly.

Answer 2

First ask your doctor.

There can be very serious consequences if you have grapefruit and are taking some types of statins.

Some statins (particularly simvastatin andatorvastatin) are metabolised by cytochrome P450 (CYP3A4) and co-administration of potent inhibitors of this enzyme (such as ‘azole’ anti-fungal agents or HIV protease inhibitors) may particularly increase plasma levels of these drugs and so increase the risk of dose-related side effects, including rhabdomyolysis.

Stick 'rhabdomyolysis' into Google and you'll stay off grapefruit.

Answer 3

high blood pressure and intense blood rigidity is a similar element. The blood rigidity machines interior the shops tend to be faulty and that's not the appropriate thank you to confirm your blood rigidity. instruction manual blood rigidity is the appropriate and if a instruction manual B/P is announcing that that's intense thna that's intense. i do in comparison to utilising the machines myself and that i prefer to apply a popular cuff. the appropriate drugs can selection from guy or woman to guy or woman. One drugs would paintings for one guy or woman and not paintings for yet another. There are quite a few categories of drugs it is used. the quite a few ordinary ones are: Coreg, Lisinopril, Atenelol are some.

Answer 4

grape fruit cause significant decreasement to the hepatic microsomal enzyme which is reponsible for lipitor metabolism
( statin group like atorvastatin ) so atorvastatin concentration
will increase and the side effect of it will be obvious like muscle cramp so you must avoid the concomitant adminstration of both
and for high blood pressure you must mention any type of hypertensive pills

Answer 5

Grapefruit is contraindicated when you take statins or some bp meds because it interferes with the action of the drug. It can alter the drug changing it's therapeutic value.

Answer 6

I do not believe grapefruit or orange juice would effect the absorbsion or action of these drugs. Certainly we do not recommend the patient not use them. MD

Answer 7

Ma y i suggest you see your doctor HE/SHE would be the best source of info. Something to do with, the natural chemicals can affect your medication, so of you go