Microbiology Question?

Question

I am working on a worksheet for Micro and need help with this question. When talking about Meningitis and the Blood Brain Barrier, Explain the statement "pencilling makes things worse before they get better??"

Any help would be appreciated.

Answer 1

Penicillin
Is a very efective antibiotic
The blood brain barier;
is a semi im -permeibal system, which safeguards the brain, from most harmful organisms ( that is its function)
unfortunately pennicilin , is not always allowed through this barrier immiediatly.
It does get through eventualy , but the patient does get worse, before he gets better .
So the sooner brain disease is diagnosed and treated with pennecilin , the swifter is the . healing role .

if you need more ' in depth ' study',
This may give you more information :

Session 1: Molecular biology of brain barrier systems-1 ... The role of p97 in iron transport across the blood-brain barier (abstract) ...lyon.inserm.fr/choroid_plexus/.../IUPS_BBB_Satellite_2001.html

mail.medacad.org
... DCX function appear critical for microtubule function in developing brain. ... takes place in a definitive red blood cells that first express the gamma and ...mail.medacad.org/www.ichg2001.org/abstracts/symposia.htm - 189k

alpha -MSH Modulates Local and Circulating Tumor Necrosis Factor-alpha in Experimental Brain Inflammation -- Rajora...
Lung biology in health and disease. New York: Dekkerin press. ... Low permeability of the blood-brain barier to nanomolar concentrations of ...www.jneurosci.org/cgi/content/full/17/6/2181 -
Project: " Drug transport across the blood-brain barier (BBB): new experimental strategies" ... Tumour Biology Laboratory Christie Hospital, FRC Path, UK ...umfcv.ro/en/Departments/FacultyOfMedicine/CellBiology/successes2.html

Answer 2

Bacterial infections are fought with bacteria.

Any concept of cure which must cross the blood-brain barrier to stave off infection, is so then done bacteriologically, naturally.

The bacterial growth with causes the damage to the meninges itself, is also elevated when and along with the introduction curative bacteria to cure the meningitis.

As all bacteria levels are elevated through this curative introduction of other bacteria, this causes damage before the good bacteria can overtake the bad, by bodily response, in this instance of necessity to cure such, meningitis.

As the strongest anti-oxidative available in the world, grape-seed extract, also crosses the blood-brain barrier, and in its anti-oxidative effects, by minimizing free-radical spin-off, it may also be a helpful tool in keeping ones brain healthier and at less risk for any diseases of the brain, and diseases stemming therefrom, as studies have shown.

CoEnzyme Q10 is also beneficial in these preventative measures for diseases in and of the brain, as COQ10 also crosses the blood-brain barrier, and is even given mention towards such preventative and curative effects, by its use, in the New England Journal of Medicine by way of test studies.

Interesting note:

Also included in this aforementioned Journal is given COQ10's studies in regards as to both preventative and curative effects having to do with HIV/AIDS, and its related symptoms. However, we know HIV/AIDS is viral, unlike spinal (meningitis).