i want to know the literature review of glibenclamide?. Is it is given only to patients who cannot use insulin

Question

How does it acts on our body? is it cause any side effects in our body? This is for submiting my project ?

Answer 1

I answered this question previously. See your earlier question.

http://en.wikipedia.org/wiki/Glibenclamide

http://www.rxlist.com/cgi/generic/glybur.htm


It is called glyburide in the US. It is used as an adjunct to diet to lower the blood glucose in patients with non-insulin-dependent diabetes mellitus (Type II) whose hyperglycemia cannot be satisfactorily controlled by diet alone.

Glibenclamide (INN), also known as glyburide (USAN), is an anti-diabetic drug in a class of medications known as sulfonylureas, used in the treatment of type II diabetes. The drug works by inhibiting ATP-sensitive potassium channels in pancreatic beta cells. This inhibition causes cell membrane depolarization, opening of voltage-dependent calcium channels, thus triggering an increase in intracellular calcium into the beta cell which stimulates insulin release. It is sold in doses of 1.25mg, 2.5mg and 5mg, under the trade names Diabeta®, Glynase® and Micronase® in the United States and Daonil®, Semi-Daonil® and Euglucon® in the United Kingdom.

It is also sold in combination with metformin under the trade name Glucovance®.

My question to you is why would somebody be unable to use insulin? Insulin is a naturally occuring hormone produced by the pancreas. With the newer human insulins available today, no one should be unable to use insulin.

Hope this helps.

Rick the Pharmacist

Answer 2

1

Answer 3

2

Answer 4

I gave you an answer in an other question, buut it is obvious you don't like to do some homework....anyway..I'll give you some more info.....

Glibenclamide

How does it work?

In patients with diabetes mellitus, there is a deficiency or absence of a hormone manufactured by the pancreas called insulin. Insulin is the main hormone responsible for the control of sugar in the blood. Glibenclamide is an antidiabetic medication which is used in those patients with maturity onset or non-insulin dependent diabetes (NIDDM). It works by lowering blood sugar levels by stimulating the production and release of insulin from the pancreas. It also promotes the movement of sugar from the blood into the cells in the body which need it. These two mechanisms, in conjunction with a diet low in sugar and fat, allow diabetics to control their blood sugar levels more effectively.
What is it used for?




Diabetes
Warning!




Avoid drinking large amounts of alcohol when taking this medicine.
Blood sugar levels should be checked regularly when taking this medicine.
Use with caution in




Elderly people
Kidney disease
Liver disease
Not to be used in




Life long inherited blood diseases which can cause a variety of symptoms, including mental health problems (porphyrias)
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.



Control of diabetes mellitus in pregnancy is usually achieved using insulin because it provides a more stable control of blood sugar. Please consult with your doctor.
Significant amounts of this medicine may pass into breast milk. It should not be used by breastfeeding mothers. Discuss this with your doctor.
Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.



Headache
Disturbances of the gut such as diarrhoea, constipation, nausea, vomiting or abdominal pain
Allergic reaction to active ingredient
Low blood glucose level (hypoglycaemia)
Weight gain
Blood disorders
Skin rashes
Severe skin rash (erythema multiforme)
The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

Answer 5

http://products.sanofi-aventis.us/diabeta/diabeta.html