My IgG levels were about 5 times the normal limit, but my IgA levels were normal. Why?

Question

I had a biopsy of the small intestine done to test for Celiac Disease, but my doctor says I don't have it. He can't give me an explanation for the elevated anti-Gliadin levels.

Does it mean I am allergic to gliadin? He says no, but what other explanation could there be?

If you don't know what I am talking about, that's okay. Just please don't answer this question. If you do know, please tell me how you know.

Thanks!

Answer 1

A "negative" biopsy result does not rule out celiac disease. Serological and HLA testing should be included in the picture. Consider getting a second opinion from an expert. Ask your doctor for a referal.

"Duodenal biopsy is still considered by most authors the “gold standard” in the diagnostic process, albeit its usefulness in the adult is still slightly controversial. If results of the histological study are negative but serologic tests are positive and CD is strongly suspected, the results of the biopsy should be reviewed with an expert gastrointestinal pathologist before additional biopsies are considered. In addition, if the histological exam yields equivocal results, it is useful to proceed with HLA typing. Although almost 40% of the general population has the HLA-DQ2 or HLA-DQ8 markers, nearly 90%-95% of CD patients have them."

Answer 2

you might have something else going on....how are your liver enzymes? what about ibs? been tested for hcv? hbv?