Why no grapefruit with Celexa?

Question

It specifically says not to take with grapefruit juice.
Just curious as to the reason.

Answer 1

same thing on my valium Rx bottle, grapefruit juice causes the stuff that the medicine is mixed with to metabolize very quickly, so you get a very fast burst from it instead of controlled, i did it once with my Rx and i felt like i drank a case of beer, not advisable, this cat was curious, and learned my lesson :))

Answer 2

There is a substance within grapefruit (and it's juice) that has a synergistic effect on some drugs. That means that the whole is greater than the sum of the parts. In such cases, it greatly enhances the efficacy of the drugs, to the extent that it can cause overdoses.

This isn't a problem with other most citrus fruits or their juices, It's also not a problem with many other types of drugs. I take some drugs with which it's a problem, and I really miss grapefruit. It's not worth endangering my life, though.

Answer 3

Grapefruit juice provides many nutrients such as vitamin C and the antioxidant lycopene. But chemicals in grapefruit interfere with enzymes that break down certain drugs in your digestive system. This can result in abnormally high blood levels of these drugs and an increased risk of serious side effects.

The exact chemical or chemicals in grapefruit juice that cause this interaction aren't known. But they're present in the pulp and peel of grapefruit as well as in the juice. For this reason, any grapefruit product — including dietary supplements that contain grapefruit bioflavonoids — can interact with some medications. You may also want to avoid tangelos, a hybrid grapefruit. They may have a similar effect.

Answer 4

Because grapefruit is very high in acid.
Celexa is a slow release drug.
The acidity in the grapefruit breaks it down to quickly and will "flood" your system.
The result will be that too much of the Celexa will be gone from your system before the next dose, which in turn will not allow it to buiid up in your system to a therapeutic level. Glad to see you are concerned. Too many people don't ask questions about their medications.

Answer 5

because it just so happens that grapefruit (any kind of it, including the fresh fruit, the juice, the sorbet..anything) is broken down in our liver by the same proteins that break down Celexa (and alot of other drugs!). But since our liver can only break down a certain amount at a time, if it's busy breaking down your grapefruit you end up getting too much drug in your blood and eventually overdose if you keep on taking it.

if you want to look into it in more detail, its the cytochrom p450 3a4 enzyme that is being used in the liver

Answer 6

grapefruit lowers the effectiveness of all medications not just celexa. grapefruit juice is highly concentrated and partially broken down so it absorbs faster. alcohol also lowers the effectiveness of antidepressants

Answer 7

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Answer 8

because of the high concentration of acid in the graprfruit juice.

Answer 9

It interferes with how the neurotransmitters get absorbed or something.