Choline Bitatrate?

Question

What could be some side effects of taking the dietary supplement "choline bitartrate"?Long term effects? Over dose effects? Damage? etc

Answer 1

Choline is an essential nutrient that is widely distributed in foods, principally in the form of phosphatidylcholine but also as free choline. It is also found in foods in the form of the phospholipid sphingomyelin. Choline is necessary for the structure and function of all cells and is crucial for sustaining life.

Choline plays many roles in the body. The three major metabolic functions of choline are as a precursor for phosphatidylcholine biosynthesis, as a precursor for acetylcholine biosynthesis and as a methyl donor. holine is also the precursor of the signaling lipids, platelet-activating factor (PAF) and sphingosylphosphoryl-choline.

Choline, as well as other substances, such as methionine, folic acid and vitamin B12, that prevent deposition of fat in the liver are known as lipotropes.

Increased choline intake has recently been recommended for pregnant and nursing women to help ensure normal fetal brain development. And, like phosphatidylcholine,choline may be helpful in some liver diseases, manic conditions, cognitive disorders, tardive dyskinesia and, possibly, some cancers.

Choline doses of up to 3 grams daily are generally well tolerated with occasional reports of nausea, diarrhea and loose stools. Higher doses have been associated with fishy body odor—particularly in those with trimethylaminuria (fish-odor syndrome). Trimethylaminuria may also occur in those with liver damage who are using high doses of choline.
High intakes of choline have been associated with excessive sweating and hypotension. There are some reports of depression or increased symptoms of depression in those using high doses of choline bitartrate.

At 7.5 grams of choline daily, nausea, diarrhea and a small decrease in blood pressure were reported in some patients. The upper limit (UL) for adults is 3.5 grams daily. Individuals that may be at increased risk of side effects with choline intakes at the UL include those with trimethylaminuria, liver disease, renal disease, depression and Parkinson's disease.

hope this helps u

Answer 2

The key brain chemical for memory is acetylcholine. A deficiency in this chemical is probably the single most common cause for declining memory. Acetylcholine is derived from the nutrient choline. Fish, especially sardines, are rich in it. Eggs are also a major source of choline, followed by liver, soy beans, peanuts, and other nuts.
A form of choline called citicholine has been used as a precursor to acetylcholine. It also boosts levels of dopamine and other neurotransmitters. It has even been used to treat victims of head injuries and strokes, since it protects brain cells from ischemia (decreased blood flow). It has also been shown to improve memory and learning in the elderly.
High doses of choline has also been proven to boost memory in adults. For example, Florence Safford of Florida International University gave forty-one people, ages fifty to eighty, 500 mg doses of choline every day for five weeks. The subjects reported having only half the number of incidents of memory lapses such as forgetting names or losing things as before. If you combine choline with other smart nutrients, such as pyroglutamate, you can achieve the same memory-boosting effect at lower doses.

Positive effects:
More alert, clear-headed, better memory and concentration; improved brain development during gestation (pregnancy).

Cautions:
None.

Dosage:
1-2 g of phosphatidyl choline daily.