what is the disease that makes a person incapable of feeling pain?

Answer 1

This is not my field of knowledge and whilst I note that the article refers to the problems asociated with the disease and anaesthesia, however, the details included in the abstract may be of interest, I therefore copy the abstract from the nominated specialists:-
The anaesthetic management of patients with
congenital insensitivity to pain with anhidrosis
by
Rozentsveig V, Katz A, Weksler N, Schwartz A,
Schilly M, Klein M, Gurman GM.
Division of Anesthesiology and Critical Care Medicine,
Soroka University Medical Center,
Faculty of Health Sciences,
Ben Gurion University of the Negev,
Beer Sheva, Israel.
Paediatr Anaesth. 2004 Apr;14(4):344-8.

ABSTRACT
BACKGROUND: Congenital insensitivity to pain with anhidrosis (CIPA, or hereditary sensory and autonomic neuropathy type IV) is a rare, autosomal recessive disease, related to a mutation in the TrkA gene, characterized by inability to sweat, insensitivity to pain and recurrent episodes of hyperpyrexia. There are two Bedouin tribes in Israel with different mutations of the TrkA gene: one in the southern region and the other in the northern region. The Soroka University Medical Center is the referral centre for the entire southern region of Israel. One in 4500 anaesthesia cases involves a patient with CIPA. METHODS: We reviewed 40 anaesthesia records of 20 patients with CIPA for anaesthetic technique and incidence of side-effects. RESULTS: Sixteen patients developed complications in the immediate perioperative period: mild hypothermia in one patient and cardiovascular events in 15 others with one case of cardiac arrest. These complications were unrelated to the anaesthetic drug administered. There were no events of hyperthermia or postoperative nausea. CONCLUSIONS: Cardiovascular complications following anaesthesia are common in patients with the southern Israel variant of CIPA. Hyperthermia, previously recognized as a major concern in patients with congenital insensitivity to pain with anhydrous, was not seen in our patients. We conclude that cardiovascular involvement is frequently encountered in CIPA patients following anaesthesia and is the major concern in their anaesthetic management.
Hope this is of help.
Matador 89

Answer 2

It's not a disease, but rather a genetic deformity. The gene is SCN9A and it is is responsible for making a protein called a voltage-gated sodium channel which is essential for pain perception. The mutation disrupts this process, making the sodium channel protein useless. Thus the pain signals never reach the brain. People with this condition can suffer severe injuries due to the fact that pain is our bodies way of communicating to us that we need to stop something. These people can suffer severe burns because they can't tell when something is too hot. They will also bite themselves or scratch themselves to the point of injury because they can't tell they are harming themselves. They are unable to tell if they have broken bones, all sorts of things. The odd thing is that they are able to feel everything else, just not pain. They can feel people hug them or tickle them, but if you pinch them, they don't register the pain.

Answer 3

The thyroid is an organ in your body located in your neck. The thyroid is important because it secretes necessary hormones to allow your body to function properly. The thyroid is not a disease, however there are a number of diseases associated with the thyroid. For example, hyperthyrodism is the production of too many hormones, while hypothyroidism is the production of too few hormones. Each individual disease will have it's own side effects and treatments.

Answer 4

Leprosy is one of the diseases which reduces or stops the feeling of pain in the affected areas. That's why the limbs can get infected so seriously, it doesn't cause pain.

Answer 5

Anhidrosis

Answer 6

congenital insensitivity to pain with anhidrosis, or CIPA