Please give me a detailed biological response. We know Penicillin and its derivatives attack the cell wall's peptidoglycan and stop the trans-peptidation reaction, and that tetracycline and all the other "-in" attack the ribosomal subunits and stop bacterial protein synthesis, but how does acyclovir (cyclovir, etc.) stop viruses?
2007-01-03 02:57:12 · 6 answers · asked by Asher Madan 3 in Health ➔ Diseases & Conditions ➔ Infectious Diseases
Acyclovir is given usually for treatment of herpes virus infection. Acyclovir is actually acycloguanosine. When it enters an infected cell, it is converted to acyclovir monophosphate by the virus encoded thymidine kinase, ie the viral DNA produces the thymidine kinase. Then cellular kinases furthur convert this inot Acyclovir di and triphosphates.
The triphosphate acts as a competitie inhibitor for viral DNA replication because when the DNA polymerase replicates the viral DNA, the acyclovir triphosphates get inserted into the chain as well. This prevents the DNA polymerase from going forward, ie, it gets inhibitited.
Therefore, viral DNA synthesis is reduced, and viral replication is reduced. Acyclovir should be give as soon as possible so that the infection can be controlled.
2007-01-03 03:08:48 · answer #1 · answered by Anonymous · 4⤊ 0⤋
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2016-05-01 12:12:30 · answer #2 · answered by Don 3 · 0⤊ 0⤋
How Does Acyclovir Work
2016-11-07 06:30:08 · answer #3 · answered by ? 4 · 0⤊ 0⤋
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2015-04-30 21:59:51 · answer #4 · answered by Suzie 1 · 0⤊ 0⤋
People have there prefrences, I guess if you can afford Valtrex then try it. It is pretty much the same thing. Acyclovir is so cheap i get a months supply from walgreens for 10 dollars, but ive never tried valtrex.
2016-03-20 03:28:11 · answer #5 · answered by Anonymous · 0⤊ 0⤋
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RE:
How does acyclovir work?
Please give me a detailed biological response. We know Penicillin and its derivatives attack the cell wall's peptidoglycan and stop the trans-peptidation reaction, and that tetracycline and all the other "-in" attack the ribosomal subunits and stop bacterial protein synthesis, but how...
2015-08-18 09:07:44 · answer #6 · answered by Ashlie 1 · 0⤊ 0⤋
Follow the link
2007-01-03 03:01:44 · answer #7 · answered by Monte T 6 · 1⤊ 1⤋
Have you looked at a PDR? Or asked a Pharmacist? One or both would know.
2007-01-03 03:03:14 · answer #8 · answered by Anonymous · 0⤊ 1⤋