Is Alzheimer's hereditary?

Question

If one of your parents had Alzheimers, is there a chance you or your siblings will get it or does it skip a generation?

Answer 1

Is Alzheimer's disease hereditary?

Familial Alzheimer’s disease (FAD) is a rare form of the disease, affecting less than 10 percent of Alzheimer’s disease patients. All FAD is early-onset, meaning the disease develops before age 65. It is caused by gene mutations on chromosomes 1, 14, and 21. Even if one of these mutated genes is inherited from a parent, the person will almost always develop early-onset Alzheimer’s disease. All offspring in the same generation have a 50/50 chance of developing FAD if one of their parents had it.

The majority of Alzheimer’s disease cases are late-onset, usually developing after age 65. Late-onset Alzheimer’s disease has no known cause and shows no obvious inheritance pattern. However, in some families, clusters of cases are seen. Although a specific gene has not been identified as the cause of late-onset Alzheimer’s disease, genetic factors do appear to play a role in the development of this form of the disease. The ApoE gene on chromosome 19 has three forms— ApoE2, ApoE3 and ApoE4. Studies have shown that people who inherit the E4 version of the gene are more likely to develop the late-onset form of Alzheimer’s disease. Scientists estimate that an additional four to seven genes influence the risk of developing late-onset Alzheimer’s disease. One of these genes is called UBQLN1 and is located on chromosome 9.

Genetic risk factors alone are not enough to cause the late-onset form of Alzheimer’s disease, so researchers are actively exploring education, diet, and environment to learn what role they might play in the development of this disease.

Answer 2

1

Answer 3

Is Alzheimers Hereditary

Answer 4

Family history is another common risk factor. However, about 5 to 15% are familial; 1⁄2 of these cases have an early onset (< 60 yr) and are typically related to specific genetic mutations.
Genetic factors are known to be important, and dominant mutations in three different genes have been identified that account for a much smaller number of cases of familial, early-onset Alzheimer's Disease(AD). For the more common form of late onset AD (LOAD), only one susceptibility gene has so far been identified called ApoE4.
Please see the web pages for more details on Alzheimer's disease.

Answer 5

Sometimes it is hereditary and sometimes it isn't.

Sometimes it skips generations, but there is not a high chance of this.

Check the link below, it explains everthing thoroughly.

Best wishes.

Answer 6

It seems like if a parent or family member has it a person's risk for getting it would be increseased. It doesn't mean however that just cause a parent or family member has it that their offspring will.
Check out the link below.

Answer 7

Yes, it can be in some cases. It is a mutation of the APO E gene, this is a commercially available test.

Answer 8

Here is a really good article that addresses that very question and how to prevent it:

http://www.everydayhealth.com/publicsite/index.aspx?puid=4aa5eb98-f1dc-4eb6-8eea-57af4ad73e09&p=1

Answer 9

there are some forms such as early onset that is hereditary.

Answer 10

Not necessarily, but not having children is hereditary, if your parents didn't have children, neither will you.