a person has a genetic defect that caused cells to produce nonfunctional adenylate cyclase.?

Question

for which of the symptoms below would we expect to see in this individual and why.
low blood calcium
diabetes insipidus
inadequate testicular and penile formation, and infertility
mother is unable to lactate
low blood sodium
myxedema(low metabolic rate, feeling chilled, constipation, lethargy)

Answer 1

This article reports such a case:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12838561

This patient had hypothyroidism, hypogonadism, transitory hypoparathyroidism, and insulin resistance. Those translate into myxedema, inadequate genital development, low blood calcium, and diabetes mellitus (not insipidus). Review your endocrine physiology, and I believe you will find a cyclic AMP mediated mechanism behind each of these findings at some level in the endocrine cascade and feedback loops for the hormones involved.

Answer 2

Except thyroid and sexual funtions all other will be directly affected.
The thyroid and sexual functions will be indirectly affected.
Also it is very difficuilt to survive with a non-functional adenylate cyclase because it is required for many hormonal axctions in the body.
Without it,peptide or peptide derivative hormones won't function.

Answer 3

well adenylate cyclase is usually often important in calcium regulation, so i'd shoot for low blood calcium. the article jerry left above though seems to suggest almost everything.