please help me!!!..... Rh-Disease!!!!!!!!!!!?

Question

i have all the basic info you can get on rh disease...but i want sopme more information about blood transfusion during war and for seniors at hospitals that cant get enough rh -negatie blood. i think it would really help me support my thesis and i need at least 80-something more notecards of info to fill out ont his. spo please if u have amy info on this..please..im begging you...help me

Answer 1

Rh disease
Do you mean Rhesus Iso-immunization where a Rh NEGATIVE mother can develop antibodies against an Rh POSITIVE baby's blood and the antibodies can enter the baby's blood stream and cause the baby's blood cells to haemolyse?

See the wiki pages below.

Okay - let's start with the basics.

There are cells in your blood called Red Blood Cells. That's cos they are red. They carry oxygen predominantly (and have other functions too but the oxygen is their prime role). They (like all the other cells of our body) have special markers on their cell membranes to let us know that they belong to us and are not some intruder cell. There are many many different markers on the red blood cell and they make up "blood types" or "blood groups". The best known of these are the ABO blood groups and the Rhesus blood groups.

The rhesus blood group was named after the Rhesus Monkey in which this sort of cell surface marker was first discovered.

From a genetic point of view it is a little complex, but for simplicity's sake it revolves around whether you have a big-D gene or a little-d gene in a certain spot which codes for this surface marker. You get these genes from your parents and so you can have a "D" or a "d" from your mother and from your father and therefore you could be DD, Dd or dd. If you have the D gene (either DD or Dd) you have a certain marker on your cell membranes and are known as Rhesus Positive. If you have the dd genotype and do NOT have the marker on your cells you are Rhesus Negative.

If a Rhesus negative person was to have Rhesus positive blood enter their body (from a transfusion, or in the case of mothers and babies this could happen with a miscarriage or at birth) then the Rhesus negative person would develop antibodies against the Rh positive blood (called Anti-D antibodies).

Okay - so the Rh disease thing occurs when you have a Rh Negative mother (dd) and Rh Positive baby. Let's say Dad was DD and so baby is now Dd (ie. Rh Positive). If baby's blood enters the mother's circulation (when there is vaginal bleeding during pregnancy, during miscarriage or during delivery of the baby) the mother can recognize this as a foreign cell and make antibodies against it (anti-D antibodies). This process takes a few days. Usually the first baby is not affected particularly much, but if it does get a dose of the anti-D antibodies, it can have haemolysis - popping of the red blood cells. Usually the next baby (also likely to be Dd in this scenario) is the one who cops it, with haemolysis of the red blood cells and "haemolytic disease of the newborn".

In order to stop the mother from becoming sensitized, when a pregnant mother who is Rh negative is thought to be at risk of baby's blood getting into her circulation she will be given a small dose of Anti-D antibodies which will go around and pop any of those blood cells quickly before the mother can develop her own antibodies to them.

Interestingly enough, if you GIVE Rh negative blood to an Rh positive person, the blood doesn't have the surface marker. With the ABO blood group the same situation exists with type O blood. So if you give O-Negative blood (which you will hear called for in the television medical dramas), this is a blood group that most people can receive the cells from without having a transfusion reaction because the cells have no surface markers for these (the major two) blood groups. This is why O-negative blood is in high demand, and often in short supply. It is used as a temporary measure until the blood of the correct blood type can be supplied.

Answer 2

RH Factor? I don't know what RH Disease is. RH Factor is normally found in children who's parents don't share the same blood type. One Positive and one Negative. Child may be one or the other also. Not a problem normally except for anymore children born to the same parents subsequently without mother having had Rogam injection following first child's birth

Answer 3

I haven't ever heard of RH disease. RH factor is something that everyone has in their blood..you are either positive or negative.
Obviously you couldn't give RH positive blood to someone with RH negative blood. Are you trying to reasearch what would happen if someone with received the wrong type of blood in a blood transfusion?

Answer 4

Have you covered the basics like the Rh factor altogether and how it actually comes from the Rhesus monkey?
After that, I wouldn't know what to tell you. No hospital is going to readily hand you the info you need. Try to find some seniors or their family members whom you could interview.

Answer 5

call 911

Answer 6

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