what does decreased gamaglobulins mean?

Question

I went for a blood test because I kept getting ill, just to check my immunity status and it was found that I had decreased gama globulins. what does this mean?

Answer 1

Gamma globulins, or Ig's, are a class of proteins in the blood, identified by their position after serum protein electrophoresis. The most significant gamma globulins are antibodies.

Gamma globulin injections are sometimes given in an attempt to temporarily boost a patient's immunity against disease. Injections are most commonly used on patients who have been exposed to hepatitis A or measles. Injections are also used to boost immunity in patients who lack the ability to produce gamma globulins because of an immune deficiency, such as X-linked agammaglobulinemia and hyper IgM syndrome. Such injections are less common in modern medical practice than they were previously, and injections of gamma globulin previously recommended for travelers have largely been replaced by the use of hepatitis A vaccine.

Gamma globulin infusions are also used to treat immunological diseases, such as immunological thrombocytopenia purpura (ITP), a disease in which the platelets are being attacked by antibodies, leading to seriously low platelet counts. Gamma globulin apparently causes the spleen to ignore the antibody-tagged platelets, thus allowing them to survive and function.

Another theory on how gamma globulin administration works in autoimmune disease is by overloading the mechanisms which degrade gamma globulins. Over loading the degradation mechanism causes the harmful gamma globulins to have a much shorter halflife in sera.

An excess is known as hypergammaglobulinemia.

A disease of gamma globulins is called a "gammopathy" (for example, in monoclonal gammopathy of undetermined significance.)

http://en.wikipedia.org/wiki/Gamma_globulin

Answer 2

Dave provided a very good summary. Also consider that both the 1999 and 2011 La Niñas were preceded by El Niños that should have had an opposite effect. In fact, the magnitude of the change in 1999 was greater than the change in 2010 since 1998 was a super El Niño. Also consider that the Sea Surface Temperatures (SST) and Ocean Heat Content (OHC) have also been stable for around a decade. In addition, it really doesn't take long for flood waters to reach an ocean. That is why Louisiana had major flooding this year. Most of the water from T.S. Irene is probably already back in the ocean due to the proximity to the coast. A reasonable person would admit that it is possible we have reached a peak in the natural climate factors that have led to 200+ years of warming that precedes our emissions of CO2. That doesn't mean CO2 has no effect, it simply demonstrates that the effect may be much less than we have been told. Several recent peer reviewed papers have demonstrated that climate sensitivity may be much less than the IPCC has claimed. Isn't it interesting that we see real science progress with the potential discovery of faster than light neutrinos without anyone calling them "maximum speed of light" deniers. This is how true science operates. It welcomes skepticism. It also demonstrates those who try to shout down climate skeptics are not real scientists.

Answer 3

Gamma Globulins are the Antibodies that your immune system uses to flight off certain types of infections. They are made by B cell lymphocytes, which proliferate in the lymph nodes. There are may types of Gamaglobulins, such as IgG, IgA, IgM, IgE. IgM is usually an early marker of infection, where IgG is what you develope for chronic immunity. IgA forms a pentamer, and I think is mostly for protecting open orifices, such as the nose, but I could be wrong on that. If your immunoglobulins are low, it could be a problem with your b cells producing them, and should be looked into by an immunologist. These antibodies are how the humoral imunne system works. An Imunoglobulin will attach itself to a cell that does not belong to the body, and this will mark it for destruction by other cells. This process is called opsonization, from the greek work relish, as it makes foreign cells more appetizing.

Answer 4

Low gamma globulin: Although gamma globulins may decrease slightly with advancing age, any decrease below the normal range if unexplained by obvious causes of protein loss (such as known renal disease), should be further evaluated with a urine immunofixation to detect possible monoclonal free light chains (Bence Jones protein) in the urine. Hypogammaglobulinemia is also seen in many patients with B-cell lymphoproliferative disorders such as chronic lymphocytic leukemia. They may be decreased with cytotoxic or immunosuppressive drug therapy (long-term steroid use, antineoplastic chemotherapy), malignant lymphoproliferative diseases, and plasma cell dyscrasias (multiple myeloma), and adult common variable immunodeficiency syndrome. If there is clinical history of susceptibility to infection in the patient or the family, then quantitative immunodiffusion or nephelometric assay for IgG, IgA, and IgM may prove helpful. Attention to lymphocytes in the peripheral blood film, presence or absence of hepatosplenomegaly and in patients over age 40, presence or absence of light chains in urine immunoelectrophoresis or immunofixation may be relevant (eg, light chain disease).

What does all of that mean? Don't try to diagnose based on 1 lab value. lol....Really, a deviation in singular lab value should be addressed and followed by a Physician. However, don't freak when you read all of the possibilities that this lab report could mean. After all, non-productive cough is a sign of lung cancer, but you don't write off every poor soul with a dry cough! Keep asking questions, never be a fraid to question your docs! Good luck and I hope it is just a benign anomaly.

Answer 5

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RE:
what does decreased gamaglobulins mean?
I went for a blood test because I kept getting ill, just to check my immunity status and it was found that I had decreased gama globulins. what does this mean?

Answer 6

Low Gamma Globulin

Answer 7

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Your explanation for where the water went doesn't fit my preconceived conclusion. THAT is your explanation's fundamental flaw. I'm not a scientist, you see. I don't do what scientists do. I don't make theories, or think of ways to test and possibly break them, or discard them if they conflict with the preponderance of evidence collected over a long period of time. What I do is make conclusions, then publicize evidence that fits my conclusions, and ignore evidence that does not fit. Thus, my talking points remain Al Gore's private jet, the dip in global sea level, and some mumbo jumbo about cosmic rays. You're not going to get me to talk about anything else. At least, not until it starts snowing where I live. I'm not about trying to understand how the world works, you see. I'm all about promoting my preconceived conclusion, and I'm not about to give your competing idea any airtime or credit. Good day.