When to take antibiotics?

Question

Hello all. I have a little dispute with my mother in law about the antibiotics my partner is taking.
He is on Amoxicillin (1 tablet 3 times a day) and Metronidazole (1 tablet 3 times a day) for a tooth that got infected.
For various reasons he takes some other tablets (Garbantina) 3 times a day at 9am, 2pm and 7pm so I've naturally been giving him his antibiotics at the same times so it doesn't get confusing whether he has taken the right tablets at the right times.
She keeps saying that he should be taking the antibiotics much more spread out and tut tutting at me!

I've read the leaflets that come with the medicine boxes but they don't state anything about it, and before anyone tells me this, some of his drugs he has to take with food which he has been doing.

Thanks for your help!

So would it be better to have the antibiotics at 7am, 3pm and 11pm so they are more spaced out, or does it not make that much difference?
Also, if you could qualify your answers and let me know how you know what you know.

Answer 1

that seems fine to me, tell her to mind her own.

Answer 2

There shouldn't be a problem with it at all. They all target certain bacteria in a specific way so there should be no interactions. The only thing i would worry about is resistance due to the fact he is taking a lot of antibiotics.
Amoxicillin is a good moderate spectrum antibiotcs and he gave him Metronidazole because it attacks anaerobic bacteria(ones that don't use oxygen) like in a tooth ache.
Tell your mother in law to trust you!


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Edit:
Amoxil is a beta lactate antibiotic which when it operates interferes with the synthesis of the peptidoglycan layer of the bacterial cell wall of aerobic bacteria. Blood levels of amoxil peak after 1-2 hrs and can stay in serum for anywhere up to 8 hours. Pretty much anywhere from 5-6 hours after the first dose you should take it again.

Metronidazole is a antibiotic which primarily treats infections caused by anaerobic bacteria and protozoa. It can stay in the body for approximately 8 hours after ingestion. It also peaks in the blood after 1-2 hours. Pretty much anywhere from 5-6 hours after the first dose you should take it again.

My two cents, there should be NO interaction between both antibiotics because they treat totally DIFFERENT microorganisms. They might kill normal flora in the body but who cares, there is millions more left and half of them do nothing beneficial anyway. You will be able to take all of them together no probs but make sure you take them at regular intervals.

Even if you take one tablet it will kill of normal flora in your body. To go over the therapeutic index level of a drug is a LOT! Taking one and then another one say 3 hours later wont do much, the blood serum level peaks after 1-2 hours but still stays in the body for a few hours after. What doctors dont want you to do is miss one totally overnight!
Hope this was some help.

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It was perfect what you said. You had a great analogy, i hate trying to explain stuff!

Answer 3

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Answer 4

i am a staff nurse and come across these drugs every working day! neva have i heard of garbantina- the nearest i can think of is gabapentin? is that what u mean?
firstly, apologies for ur partner's need to take such antibiotics.
amoxicillin= normally given every 8 hours, to ensure a steady level of the drug in the bloodstram, but if it is one or 2 hours either side, it is not going to do any harm. it is a broad- spectrum penicillin
metronidazole=used for microbial bacteria- it is an antimicrobial drug. again metronidazole should be taken every 8 hours for the same reason as amoxycilin.
hope this is of use.

Answer 5

Hey ! I'm no medic or dentist but I work in the industry and understand quite a bit about medicines, their use and doses. My only concern here is that I really hope a dentist was consulted who prescribed this medicine for your friend. You have not stated the doses of any of the medicines taken. Amoxy with metronidazole is all right for about 5 days. Amoxy at 500mg should be taken 2X at 12 hr intervals.That goes for metronidazole at 400mg tabs..

If the tooth infection has not cleared please ask this person to see a dentist pronto....and that is please. This actually should not be discussed at Yahoo Answers unless one is suspecting an overdose or some hanky panky.

Hope this helps and again go see a dentist if need be.

Answer 6

No idea what garbantina might be. Recheck your spelling and ask your pharmacist about possible interactions. If it's OK to take them together, then there should be no problem with your schedule. The peaks and valleys of amoxicillin and metronidazole in his bloodstream shouldn't be important in this situation. When your husband's better, consider divorce and marrying an orphan. There are very few cures for mothers-in-law.

Answer 7

I am an Ex-Air Force Medical Laboratory Technician.

First off, check your spelling on "Garbantina" I cannot find any information on that spelling. Need to make sure we are talking about the right medication.

Now for the antibiotics... The dosage schedule for antibiotics must be followed exactly, or as close to it as possible. Your mother is correct. I will explain why.

When you take any kind of pill, the amount of that medication in your blood stream will be at it's highest level at some point, and then will drop off to nothing over time. *If you could imagine a rollercoaster, you go up the hill, and then you go back down to nothing*. Well, before that drug content goes down to nothing, we would want to take another pill to ensure that our body does not go without. *You will want another hill for your roller coaster so that your ride is not over*. If you keep taking the pills at selected times, *your rollercoaster keeps getting hills*, then there will be no point at which you are going without. Well, the drug world does not want us to be on a rollercoaster...it wants us to be on a plateau. There is a certain quantity of a drug that has been established as being "therapeutic amount". It is the amount of drug present in the blood stream in order to work on a therapeutic level. The difference in the height of the hills from the valleys in the rollercoaster will be higher than the valleys, but lower than the hills. We would have to call that height the median level. That median level is our drug plateau as long as we keep on schedule. So, with antibiotics, we also have to take into account the life cycle of bacteria. Depending on the bacteria, reproduction takes place over a certain known time frame. During these times of reproduction, if the content of antibiotic is lower than the plateau "therapeutic level", then the bacteria will reproduce, and you will not get better. Some drugs and antibiotics need a higher plateau (therapeutic level) to work. In these cases, a higher dosage is taken *there are higher hills on the rollercoaster* If the correct time frame is not followed with antibiotics, then your body will experience a time under the therapeutic level. If this happens, the bacteria that is still alive will be able to reproduce because there is not enough drug in your system. You have to keep the drug at it's therapeutic level. With antibiotics, you have to space all the pills exactly the same hours apart from eachother. If you give him the antibiotics too close together, then the serum level (amount in the blood stream)will go higher than the therapeutic level. When this happens, the antibiotic starts killing off other bacteria in the body (natural flora)that you do not want to kill. That is why many women get a yeast infection when they are on antibiotics....yeast is opportunistic, and with a lowered amount of normal flora competing for food, the yeast will spread.

That is why he is on x3 daily q.8 h.

For the Garbantina you mentioned, I don't know if it is the right spelling or if it is a generic name for something. If he has to take it at breakfast, lunch, dinner...then it has a different half-life (the time it takes your rollercoaster to go from the start of the ride, over the first hill, and to the therapeutic line) He will have to take the pills at separate times.

Sorry, but I do not have a link to back me up on this information. I looked around the internet, but I couldn't find anything useful. I'm sure you did too.

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UPDATE
Hey YOPPO, not too bad coming from a lab tech huh?

Anyway, I hope we have throughly answered your question dear asker. Have fun deciding on the best answer!

Answer 8

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Answer 9

Taking tablets 3 times a day,there are24 hours in a day
so tablet must be spaced out more,
One first thing in the morning.
One last thing before bed.
And the other one smack in between the two.
I take one at 7am one at 3pm one at 11pm an 8hr spacing.
because it obvious it would be impracticable.to take during night.
I am a long time pill taker and i am afraid mum in law
is correct this time Sorry.

Answer 10

just let the man complete his dose of antibiotics......

Answer 11

Tell her to mind her own damned business.