can i take vitamin E daily?

Question

is vitamin e good for digestive system and has no side effects?

Answer 1

Yes you can take Vitamin E daily.
Alpha-tocopherol is traditionally recognized as the most active form of vitamin E in humans, and is a powerful biological antioxidant. The measurement of "vitamin E" activity in international units (IU) was based on fertility enhancement by the prevention of spontaneous abortions in pregnant rats relative to alpha tocopherol. It increases naturally to about 150% of normal in the maternal circulation during human pregnancies. 1 IU of vitamin E is defined as the biological equivalent of 0.667 milligrams of RRR-alpha-tocopherol (formerly named d-alpha-tocopherol, or of 1 milligram of all-rac-alpha-tocopheryl acetate (commercially called dl-alpha-tocopheryl acetate, the original d,l- synthetic molecular mix, properly named 2-ambo-alpha-tocopherol, is no longer manufactured). The other R,R,R tocopherol vitamers are slowly being recognized as research begins to elucidate their additional roles in the human body. Many naturopathic and orthomolecular medicine advocates suggest that vitamin E supplements contain at least 20% by weight of the other natural vitamin E isomers. Commercially available blends of natural vitamin E include "mixed tocopherols" and "high gamma tocopherol" formulas. Also selenium, Coenzyme Q10, and ample vitamin C have been shown to be needed for effective antioxidant recycling of tocopherols.

Tocotrienols, with four d- isomers, also belong to the vitamin E family. The four tocotrienols have structures corresponding to the four tocopherols, except with an unsaturated bond in each of the three isoprene units that form the hydrocarbon tail. Tocopherols have a saturated phytyl tail.

Antioxidants such as vitamin E act to protect cells against the effects of free radicals, which are potentially damaging by-products of the body's metabolism. Free radicals can cause cell damage that may contribute to the development of cardiovascular disease and cancer. Vitamin C and other anti-oxidants recycle vitamin E end-products back into effective suppressors of free radicals. Studies are underway to determine whether vitamin E might help prevent or delay the development of those chronic diseases.

Commercial vitamin E supplements can be classified into several distinct categories: fully synthetic vitamin E, "d,l-alpha-tocopherol", the most inexpensive, most commonly sold supplement form usually as the acetate ester; semisynthetic "natural source" vitamin E esters, the "natural source" forms used in tablets and multiple vitamins; highly fractionated natural d-alpha tocopherol; less fractionated "natural mixed tocopherols"; high gamma-tocopherol fraction supplements; and tocotrienol supplements.

Synthetic vitamin E is now manufactured as all-racemic alpha tocopheryl acetate with three chiral centers, with only one alpha tocopherol molecule (moiety) in 8 molecules as actual R,R,R-alpha tocopherol. Synthetic all-rac vitamin E is usually marked as d,l-tocopherol or d,l-tocopheryl acetate, with 50% d-alpha tocopherol moiety and 50% l-alpha-tocopherol moiety, as synthesized by an earlier process with only one chiral center. The synthetic form is not as active as the natural alpha tocopherol form. The 1950's thalidomide disaster with numerous severe birth defects is a common example of d- vs l- epimer forms type problem with synthesized racemic mixtures. Information on any side effects of the synthetic vitamin E epimers is not readily available. Naturopathic and orthomolecular medicine advocates have long considered the synthetic vitamin E forms to be with little or no merit for cancer, circulatory and heart diseases.

Semisynthetic "natural source" vitamin E, manufacturers convert the common natural beta, gamma and delta tocopherol isomers into esters using acetic or succinic acid and add methyl groups to yield d-alpha tocopheryl esters such as d-alpha tocopheryl acetate or d-alpha tocopheryl succinate. These tocopheryl esters are more stable and are easy to use in tablets and multiple vitamin pills. Because only alpha tocopherols were officially counted as "vitamin E" in supplements, refiners and manufacturers faced enormous economic pressure to esterify and methylate the other natural tocopherol isomers, d-beta-, d-gamma- and d-delta-tocopherol into d-alpha tocopheryl acetate or succinate. However these alpha tocopheryl esters have been shown to be variably and less efficiently absorbed in humans than in the original normative tests using rats.[3] Tocopheryl nicotinate and tocopheryl linolate esters are used in cosmetics and some pharmaceuticals. In the healthy human body, the semisynthetic forms are easily de-esterified over several days, primarily in the liver, but not for common problems in premature babies, aged or ill patients.

"Mixed tocopherols" in the US contain at least 20% w/w other natural R,R,R- tocopherols, i.e. R,R,R-alpha-tocopherol content plus at least 25% R,R,R-beta-, R,R,R-gamma-, R,R,R-delta-tocopherols. Some premium brands may contain 200% w/w or more of the other tocopherols and measurable tocotrienols. Some mixed tocopherols with higher gamma-tocopherol content are marketed as "High Gamma-Tocopherol". The label should report each component in milligrams, except R,R,R-alpha-tocopherol may still be reported in IU.


[edit] Recommended amounts
The U.S. Dietary Reference Intake (DRI) Recommended Daily Amount (RDA) for a 25-year old male for Vitamin E is 15 mg/day. This is approximately 15 IU/day. Specifically, The natural form of alpha-tocopherol: RRR-alpha-tocopherol maintain 1.5 IU/mg.

The DRI for vitamin E is based on the alpha-tocopherol form because it is the most active form as originally tested. Results of two national surveys, the National Health and Nutrition Examination Survey (NHANES III 1988-91) and the Continuing Survey of Food Intakes of Individuals (1994 CSFII) indicated that the dietary intakes of most Americans do not provide the recommended amounts of vitamin E. However, a 2000 Institute of Medicine (IOM) report on vitamin E states that intake estimates of vitamin E may be low because energy and fat intake is often underreported in national surveys and because the kind and amount of fat added during cooking is often not known. The IOM states that most North American adults get enough vitamin E from their normal diets to meet current recommendations. However, they do caution individuals who consume low fat diets because vegetable oils are such a good dietary source of vitamin E. "Low-fat diets can substantially decrease vitamin E intakes if food choices are not carefully made to enhance alpha-tocopherol intakes". Vitamin E supplements are absorbed best when taken with meals. (Iuliano 2001) Because vitamin E can act as an anticoagulant and may increase the risk of bleeding problems many agencies have set an upper tolerable intake level (UL) for vitamin E at 1,000 mg (1,500 IU) per day.[4]


[edit] Factors in vitamin E deficiency
There are three specific situations when a vitamin E deficiency is likely to occur. It is seen in persons who cannot absorb dietary fat, has been found in premature, very low birth weight infants (birth weights less than 1500 grams, or 3.5 pounds), and is seen in individuals with rare disorders of fat metabolism. A vitamin E deficiency is usually characterized by neurological problems due to poor nerve conduction.

Individuals who cannot absorb fat may require a vitamin E supplement because some dietary fat is needed for the absorption of vitamin E from the gastrointestinal tract. Anyone diagnosed with cystic fibrosis, individuals who have had part or all of their stomach removed, and individuals with malabsorptive problems such as Crohn's disease, liver disease or pancreatic insufficiency may not absorb fat and should discuss the need for supplemental vitamin E with their physician (3). People who cannot absorb fat often pass greasy stools or have chronic diarrhea.

Very low birth weight infants may be deficient in vitamin E. These infants are usually under the care of a neonatologist, a pediatrician specializing in the care of newborns, who evaluates and treats the exact nutritional needs of premature infants.

Abetalipoproteinemia is a rare inherited disorder of fat metabolism that results in poor absorption of dietary fat and vitamin E. The vitamin E deficiency associated with this disease causes problems such as poor transmission of nerve impulses, muscle weakness, and degeneration of the retina that can cause blindness. Individuals with abetalipoproteinemia may be prescribed special vitamin E supplements by a physician to treat this disorder.

Also, in adults, erythrocyte membrane fragility results as the erythrocytes are oxidized.


[edit] Current issues and controversies about vitamin E
Conventional medical studies on "vitamin E", as of 2006 and as below, use either a synthetic all-racemic ("d,l-") alpha tocopheryl ester (acetate or succinate) or a semi-synthetic d-alpha tocopheryl ester (acetate or succinate). Proponents of megavitamin, orthomolecular and naturally based therapies have advocated, for the last two thirds of a century, and have used the natural tocopherols, often mixed tocopherols with an additional 25% - 200% w/w d-beta-, d-gamma-,[5][6] and d-delta-tocopherol. Based on various clinical, experimental, patent, and individual data, natural health proponents have long held[7][8] that the other poorly studied tocopherols, especially the abundant d-gamma-tocopherol,[9] in combination with other antioxidants such as selenium, coQ10, vitamin C, vitamin K2, mixed carotenoids, and lipoic acid, provide unique biochemical benefits.[10] The methodology, interpretation and reporting of conventional vitamin E studies have even become contentious within conventional medicine circles.[11]


[edit] Vitamin E and heart disease
Preliminary research has led to a widely held belief that vitamin E may help prevent or delay coronary heart disease. Researchers are fairly certain that oxidative modification of LDL-cholesterol (sometimes called "bad" cholesterol) promotes blockages in coronary arteries that may lead to atherosclerosis and heart attacks. Vitamin E may help prevent or delay coronary heart disease by limiting the oxidation of LDL-cholesterol. Vitamin E also may help prevent the formation of blood clots, which could lead to a heart attack. Observational studies have associated lower rates of heart disease with higher vitamin E intake. A study of approximately 90,000 nurses suggested that the incidence of heart disease was 30% to 40% lower among nurses with the highest intake of vitamin E from diet and supplements. The range of intakes from both diet and supplements in this group was 21.6 to 1,000 IU (32 to 1,500 mg), with the median intake being 208 IU (139 mg). A 1994 review of 5,133 Finnish men and women aged 30 - 69 years suggested that increased dietary intake of vitamin E was associated with decreased mortality (death) from heart disease.

But even though these observations are promising, randomized clinical trials have consistently shown lack of benefit to the role of vitamin E supplements in heart disease. The Heart Outcomes Prevention Evaluation (HOPE) Study followed almost 10,000 patients for 4.5 years who were at high risk for heart attack or stroke. In this intervention study the subjects who received 265 mg (400) IU of vitamin E daily did not experience significantly fewer cardiovascular events or hospitalizations for heart failure or chest pain when compared to those who received a sugar pill. The researchers suggested that it is unlikely that the vitamin E supplement provided any protection against cardiovascular disease in the HOPE study. This study is continuing, to determine whether a longer duration of intervention with vitamin E supplements will provide any protection against cardiovascular disease.

Furthermore, meta analysis of several trials of antioxidants, including vitamin E, have not shown any benefit to vitamin E supplementation for preventing coronary heart disease.[12] Indeed, vitamin E supplementation may increase the risk for heart failure.[13]

Orthomolecular and naturopathetic medicine use much different types of vitamin E, the natural mixed tocopherols, and other supportive cofactors such as, selenium, vitamin C, carnitine, lysine, and co-Q10 for various cardiovascular diseases.[14][15] See also Orthomolecular_medicine:Vitamin E controversy.


[edit] Vitamin E and cancer
Antioxidants such as vitamin E help protect against the damaging effects of free radicals, which may contribute to the development of chronic diseases such as cancer. Vitamin E also may block the formation of nitrosamines, which are carcinogens formed in the stomach from nitrites consumed in the diet. It also may protect against the development of cancers by enhancing immune function. To date, human trials and surveys that have tried to associate vitamin E with incidence of cancer remain generally inconclusive.

Some evidence associates higher intake of vitamin E with a decreased incidence of prostate cancer (See ATBC study) and breast cancer. Some studies correlate additional cofactors, such as specific vitamin E isomers, e.g. gamma-tocopherol, and other nutrients, e.g. selenium, with dramatic risk reductions in prostate cancer.[16] However, an examination of the effect of dietary factors, including vitamin E, on incidence of postmenopausal breast cancer in over 18,000 women from New York State did not associate a greater vitamin E intake with a reduced risk of developing breast cancer.

A study of women in Iowa provided evidence that an increased dietary intake of vitamin E may decrease the risk of colon cancer, especially in women under 65 years of age. On the other hand, vitamin E intake was not statistically associated with risk of colon cancer in almost 2,000 adults with cancer who were compared to controls without cancer. At this time there is limited evidence to recommend vitamin E supplements for the prevention of cancer.

Recent studies also show that vitamin E acts as an effective free radical scavenger and can lower the incidence of lung cancer in smokers. The effects are opposite to that of the clinical trials based on administering carotenoid to male smokers, that resulted in increased risk of lung cancer. Hence vitamin E is an effective antagonist to the oxidative stress that is imposed by high carotenoids in certain patients.


[edit] Vitamin E and cataracts
A cataract is a condition of clouding of the tissue of the lens of the eye. They increase the risk of disability and blindness in aging adults. Antioxidants are being studied to determine whether they can help prevent or delay cataract growth. Observational studies have found that lens clarity, which is used to diagnose cataracts, was better in regular users of vitamin E supplements and in persons with higher blood levels of vitamin E. A study of middle aged male smokers, however, did not demonstrate any effect from vitamin E supplements on the incidence of cataract formation. The effects of smoking, a major risk factor for developing cataracts, may have overridden any potential benefit from the vitamin E, but the conflicting results also indicate a need for further studies before researchers can confidently recommend extra vitamin E for the prevention of cataracts. It is important to note that the term "cataract" may be used in common parlance for an opacity involving any tissue of the eye, for example a corneal scar. Thus a character in theater or on television who is blind from cataracts might have white instead of clear corneas, covering over the iris and pupil. Since the lens is behind the pupil, real cataracts are difficult to see without special instrumentation, so people with cataracts have rather normally appearing eyes.


[edit] Vitamin E and Age Related Macular Degeneration (AMD)
AMD is the leading cause of visual impairment and blindness in the United States and the developed world among people 65 years and older. Roughly 30% of the human population 75 years or older has some degree of AMD. As the average life span of humans continues to increase, particularly in the developed countries, the incidence of AMD is expected to nearly double within the next 25 years. What is particularly devastating about advanced forms of this condition is that it involves loss of central vision - affecting abilities to read and see faces. domized placebo controlled Age-Related Eye Disease Study (AREDS) trial sponsored by the National Eye Institutes showed that people at high risk of developing advanced stages of AMD lowered their risk by about 25 percent when treated for 5 years with a high-dose combination of vitamin C, vitamin E, beta-carotene, and zinc. Studies on vitamin E alone have been contradictory at best, with some showing no association between levels of vitamin E intake and progression of AMD.


[edit] Vitamin E and Alzheimer's disease
Alzheimer's disease is a wasting disease of the brain. An observational trial conducted by The Johns Hopkins University Bloomberg School of Public Health found that when vitamin E is taken daily in large doses (400-1000IU) in combination with vitamin C (500-1000mg) the onset of Alzheimer's was reduced between 64 and 78%.[17]


[edit] Vitamin E and Parkinson's disease
In May 2005, The Lancet Neurology published a study suggesting that vitamin E may help protect against Parkinson's disease. Individuals with moderate to high intakes of dietary vitamin E were found to have a lower risk of Parkinson's. No conclusion was drawn about whether supplemental vitamin E has the same effect, however.[18]


[edit] Health issues of vitamin E supplementation
The overall wisdom of synthetic and semisynthetic vitamin E supplementation has been increasingly questioned in recent years. A controversial[10] 2005 meta analysis of vitamin E esters supplementation questioned the benefit of high dosage alpha tocopheryl esters.[19] This meta analysis found that "high dose" vitamin E esters(>400 units/day) were associated with an all cause mortality risk difference of 39 per 10,000 persons, including some trials using synthetic beta-carotene and other cofounders to supply the mortality. Further, the Miller group claimed a significant relationship between dose and all-cause mortality, with increased risk with doses exceed 150 units per day.

However, "toxicity symptoms have not been reported even at intakes of 800 IU per kilogram of body weight daily for 5 months" according to the Food and Nutrition Board (Rosenberg, et al), an amount that corresponds to 60,000 IU per day for a 75 kg adult.


[edit] Use during pregnancy
Recent studies into the use of both Vitamin C and the single isomer vitamin E esters as possible help in preventing oxidative stress leading to pre-eclampsia has failed to show significant benefits,[20] but did increase the rate of babies born with a low birthweight in one study.[21] However, earlier work that suggested vitamin K (similar structures to natural E isomers) and C together have 91% benefit in nausea and vomiting remains unaddressed.[

Answer 2

I used to take 400 IU (International Units) of vitamin E every day until I read that people who take that much vitamin E have a 5% higher death rate than other people. There was no such problem with people who took 200 IU a day.

The question remains was the vitamin E killing people, or were sick people taking vitamin E? I still have some 400 IU vitamin E capsules, and I take one every couple of weeks. Unlike most vitamins, which are water soluble and go through your system quickly, vitamin E is fat soluble and stays with you for months.

Answer 3

I was taking vitamin E as a daily supplement.. You'll be fine.. just make sure not to take too much (although, I do not believe there are very many ill side effects from overdosing on Vitamin E)..

There were no side effects for me, except positive ones (my fingernails grew faster and stronger, my hair was shiny, etc), but every person is different. If you are seriously concerned, call you doctor and speak with a nurse who can look at your medical charts and give you professional advice.

Answer 4

Vitamin E is taken daily by millions of people and has little or no downside at the recommended doses. Do not take more than 800 IU daily unless your doctor recommneds it.
It is good for every cell in your body.

Answer 5

Its generally considered safe to take on a daily basis, as long as you follow the recommended dosage. Its impossible to say whether you will experience side effects. Some people do, and some don't. Its best to consult your doctor before taking any supplements. Good luck.

Answer 6

What form of Vitamin E are you taking? If it is all natural mixed tocopherols and mixed tocotrienols, then you are probably fine. But, it is highly unlikely you are taking these forms. Best wishes and good luck.

Answer 7

Keep in mind not to take excess amounts.
"Daily doses of 150 IU or less had no adverse effects, and might even offer health benefits. Risk of death started to increase above this level, and became significant at 400 IU and higher." (Gould, 2004).(Please check for the reference.)

Answer 8

yes its really good all over .....i take it everyday ...its really nice ....and have no side effects ..and helps healthy skin,,,hair and mainly the heart system remains balanced if u have nice habbit of regular vitamin E u will be saved from artery diseases...and make sure no higher doses u take ..coz i saw it on internet somewhere it said high dose can cause internal brain bleeding....

Answer 9

I know is very good for a healthy skin and no side effects

Answer 10

yes also helps you to blow out huge loads of j i z z!