Affect of Gender, Age, and Weight on Drug Effectiveness?

Question

I am building a basic drug simulation program for a project right now where you are tasked with modeling the concentration of whatever drug in the body, specifically the oral, central, and peripheral compartments. To enhance my model I am looking to add gender, age, and weight factors.


My question specifically: What are the some general effects of gender, age, and weight on the metabolization of drugs in the body?

I guess I'm just looking to confirm what I think:

Increasing age--decreasing metabolism
The heavier you are the slower you metabolize

Not very sure about the gender factor though

Answer 1

With age, the more older you become the slower is your metabolism. That is why geriatric patients have smaller doses than young adults. With regards to weight, the heavier one is, the more concentration of the drugs is needed to effect the same result, like for example the children maybe of the same age but they have to be weighed and appropriate adjustments are made with the dosage. As with gender, men have usually more body mass than female that is why they have increased dosage than women. But this does not apply to all drugs. There are drugs that has a standard dose no matter what the weight of the person is, as long as they are of the same age.

Answer 2

All depends on state of health, due to age sex and that depends on what is eaten by her/him