what are the recent developments in NSAIDs?

Question

I want to do a paper on NSAID,so I need some materials on its recent developments.

Answer 1

The use of peruvian bark was popular prior to the development of proprietary NSAIDs as it did contain aspirin. The prototypical NSAID (non steroidal anti inflammatory drug) was salsalate which is still available. A man that worked for Bayer in Germany's father had rhematoid arthritis and salsalate did not work. By adding an acetyl group to the salsalate aspirin (acetyl salicylic acid) was born. The only recent development has been the identification of COX (cyclo oxygenase) 2 inhibitors - previous NSAIDs were thought to be nonspecific although the original salsalate turns out to be a COX2 also. Of the 3 COX2 inhibitors introduced in the US only celecoxib (Celebrex) remains. Rofecoxib and valdecoxib were withdrawn for different reasons but in both cases it was more legal than medical. ARAMIS is the 'rheumatoid' organization in this country and they regard salsalate as the safest and most effective NSAID although some would say that this is an over simplification. Nonetheless salsalate remains my NSAID of choice for those willing to take more than 1 dose daily. Salsalate is also unique in that it appears to be safe in those allergic to aspirin or other NSAIDs. To my knowledge there is nothing different or unique on the horizon regardings NSAIDs. If you require additional information please let me know and good luck with your paper.

Answer 2

Merck says they have replaced Vioxx. It's called Arcoxia and supposedly doesn't cause the heart problems that Vioxx did. But it has other problems. Here's a news story:

http://biz.yahoo.com/cnnm/061113/111306_arcoxia_merck.html?.v=2