sickle trait?

Question

my first born son has sickle cell trait. but my 2nd born was not diagnosed with it and they both have the same father how can that be?

Answer 1

Well, if you and your husband both are trait, then for each pregnancy there is 25% cahnce for a diseased child ,50% trait and 25% will not get the gene at all. if one of you is trait, then for each pregnancy there is %50 chance for trait and 50% not carrying the gene at all

Answer 2

Each parent has two copies of the hemoglobin gene (of all genes). The father is obviously a carrier and so has one regular gene and one sickle cell gene. Upon fertilization, each gene has a 50/50 chance of being inherited. That doesn't mean that you will always see that ratio, especially because people don't have enough babies for the ratio to present itself.

In your children's case, the ratio presented itself only after two. Thankfully, it's only the trait and not the disease.

Answer 3

If the father is a carrier, this is out it would work. A carrier has one regular gene and one sickle gene. Each sperm has either the sickle gene OR the regular gene, not both. So, each time you have a child, there is a 50/50 chance of him or her inheriting the sickle cell gene.

Answer 4

Each of our feature is determine by a pair of genes. There are dominant genes (just takes one of them to show the trait) and recessive genes (both genes must be recessive for the trait to show) Sickle cell is a recessive trait. Since neither u or ur partner has it, each of you must have the normal dorminant gene and the recessive sickle gene. By chance of permutation, there is a 25% chance that your children will have the sickle trait (got a recessive gene from each parent) . So it is possible for one kid to be normal and the other to be sickle and both of them are from the same parent.

Maybe you would like to go to this link for more details :
http://ghr.nlm.nih.gov/condition=sicklecellanemia

Hope this helps

Answer 5

Do not worry too much as he has trait not the disease. everyone on here seems to have explained it pretty well. Here is another link for you to check if its helpful to you. Most major hospitals should have a sickle cell 'clinic' which may run at least once a week if not more. You can speak to trained medical staff, get information and attend meetings if any of it helps. Your GP or health visitor should be able to put you in touch or you can contact your hospital direct.

http://healthweb.blink.org.uk/advice/commoninfo.php?key=52&lang=2

http://en.wikipedia.org/wiki/Sickle_cell_trait

[e-mail]
Sickle Cell Society
54 Station Road
London, NW10 4UA
UK

Tel [phone]
Fax [phone]

Answer 6

Because Sickle cell is a recessive trait....your son had a 25% of full blown disease (ss) 50% of a carrier(Ss) and 25% of normality (SS).
part of the Punet square which determine genetic disease...Due to you both being carriers.

S=normal s= disease

Mom S s
Dad S SS Ss
........s Ss ss

Answer 7

you or your children's father could be a carrier. that doesn't mean that each child will inherit the gene. there is a 50/50 chance.

Answer 8

like blue eyes, not everyone who has the blue eyed father has blue eyes, simply one has it and one doesnt.